ArticleAmerican journal of physiology. Renal physiology2011
Nephron blood flow dynamics measured by laser speckle contrast imaging.
Article in American journal of physiology. Renal physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Beyond canonical homeostasis: Dynamic, plastic, and intermittently unregulated physiology as the norm.Physiological reports · 2026Review
- Measuring nephron number in the healthy and diabetic rat kidney in vivo using MRI without contrast agents.American journal of physiology. Renal physiology · 2026Article
- The nephron arterial network and its interactions: nonlinear and information theoretic analyses.Frontiers in network physiology · 2026Article
- Laser speckle contrast imaging of hepatic microcirculation.Biomedical optics express · 2025Article
- Resting-state MRI reveals spontaneous physiological fluctuations in the kidney and tracks diabetic nephropathy in rats.American journal of physiology. Renal physiology · 2024Article
- In vivo mapping of hemodynamic responses mediated by tubuloglomerular feedback in hypertensive kidneys.Scientific reports · 2023Article
- Lossless temporal contrast analysis of laser speckle images from periodic signals.Biomedical optics express · 2023Article
- The assessment of cortical hemodynamic responses induced by tubuloglomerular feedback using in vivo imaging.Physiological reports · 2023Article
- Reduced tubuloglomerular feedback activity and absence of its synchronization in a connexin40 knockout rat.Frontiers in network physiology · 2023Article
- Mapping single-nephron filtration in the isolated, perfused rat kidney using magnetic resonance imaging.American journal of physiology. Renal physiology · 2022Article
- Synchronization in renal microcirculation unveiled with high-resolution blood flow imaging.eLife · 2022Article
- Multi-scale laser speckle contrast imaging of microcirculatory vasoreactivity.Biomedical optics express · 2022Article
- Real-time visualization of renal microperfusion using laser speckle contrast imaging.Journal of biomedical optics · 2021Article
- Architecture of the rat nephron-arterial network: analysis with micro-computed tomography.American journal of physiology. Renal physiology · 2017Article
- Modeling of Kidney Hemodynamics: Probability-Based Topology of an Arterial Network.PLoS computational biology · 2016Article
- Estimation of vessel diameter and blood flow dynamics from laser speckle images.Biomedical optics express · 2016Article
- Transfer Function Analysis of Dynamic Blood Flow Control in the Rat Kidney.Bulletin of mathematical biology · 2016Article
- Descending Vasa Recta Endothelial Membrane Potential Response Requires Pericyte Communication.PloS one · 2016Article
- Laser speckle imaging of intra organ drug distribution.Biomedical optics express · 2015Article
- Recent advances in renal hemodynamics: insights from bench experiments and computer simulations.American journal of physiology. Renal physiology · 2015Review
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Authors and funding
6 authors.
Funding
Abstract
Tubuloglomerular feedback (TGF) has an important role in autoregulation of renal blood flow and glomerular filtration rate (GFR). Because of the characteristics of signal transmission in the feedback loop, the TGF undergoes self-sustained oscillations in single-nephron blood flow, GFR, and tubular pressure and flow. Nephrons interact by exchanging electrical signals conducted electrotonically through cells of the vascular wall, leading to synchronization of the TGF-mediated oscillations. Experimental studies of these interactions have been limited to observations on two or at most three nephrons simultaneously. The interacting nephron fields are likely to be more extensive. We have turned to laser speckle contrast imaging to measure the blood flow dynamics of 50-100 nephrons simultaneously on the renal surface of anesthetized rats. We report the application of this method and describe analytic techniques for extracting the desired data and for examining them for evidence of nephron synchronization. Synchronized TGF oscillations were detected in pairs or triplets of nephrons. The amplitude and the frequency of the oscillations changed with time, as did the patterns of synchronization. Synchronization may take place among nephrons not immediately adjacent on the surface of the kidney.
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