ArticleJournal of neurophysiology2011
Differential modulation of synaptic strength and timing regulate synaptic efficacy in a motor network.
Article in Journal of neurophysiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Neuromodulators Generate Multiple Context-Relevant Behaviors in Recurrent Neural Networks.Neural computation · 2026Article
- IeLife · 2024Article
- IbioRxiv : the preprint server for biology · 2024Article
- The differential contribution of pacemaker neurons to synaptic transmission in the pyloric network of the Jonah crab,Journal of neurophysiology · 2019Article
- Graded Transmission without Action Potentials Sustains Rhythmic Activity in Some But Not All Modulators That Activate the Same Current.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Article
- Neuromodulation of neurons and synapses.Current opinion in neurobiology · 2014Review
- Effects of synaptic plasticity on phase and period locking in a network of two oscillatory neurons.Journal of mathematical neuroscience · 2014Article
- Dopamine: a parallel pathway for the modulation of spinal locomotor networks.Frontiers in neural circuits · 2014Review
- Activation of high and low affinity dopamine receptors generates a closed loop that maintains a conductance ratio and its activity correlate.Frontiers in neural circuits · 2013Article
- Flight and walking in locusts-cholinergic co-activation, temporal coupling and its modulation by biogenic amines.PloS one · 2013Article
- Neuromodulatory changes in short-term synaptic dynamics may be mediated by two distinct mechanisms of presynaptic calcium entry.Journal of computational neuroscience · 2012Article
- Neuromodulator-evoked synaptic metaplasticity within a central pattern generator network.Journal of neurophysiology · 2012Article
- Review
- Patterns of presynaptic activity and synaptic strength interact to produce motor output.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Tonic nanomolar dopamine enables an activity-dependent phase recovery mechanism that persistently alters the maximal conductance of the hyperpolarization-activated current in a rhythmically active neuron.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Peptide neuromodulation of synaptic dynamics in an oscillatory network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Article
- Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Neuromodulators modify network output by altering neuronal firing properties and synaptic strength at multiple sites; however, the functional importance of each site is often unclear. We determined the importance of monoamine modulation of a single synapse for regulation of network cycle frequency in the oscillatory pyloric network of the lobster. The pacemaker kernel of the pyloric network receives only one chemical synaptic feedback, an inhibitory synapse from the lateral pyloric (LP) neuron to the pyloric dilator (PD) neurons, which can limit cycle frequency. We measured the effects of dopamine (DA), octopamine (Oct), and serotonin (5HT) on the strength of the LP→PD synapse and the ability of the modified synapse to regulate pyloric cycle frequency. DA and Oct strengthened, whereas 5HT weakened, LP→PD inhibition. Surprisingly, the DA-strengthened LP→PD synapse lost its ability to slow the pyloric oscillations, whereas the 5HT-weakened LP→PD synapse gained a greater influence on the oscillations. These results are explained by monoamine modulation of factors that determine the firing phase of the LP neuron in each cycle. DA acts via multiple mechanisms to phase-advance the LP neuron into the pacemaker's refractory period, where the strengthened synapse has little effect. In contrast, 5HT phase-delays LP activity into a region of greater pacemaker sensitivity to LP synaptic input. Only Oct enhanced LP regulation of cycle period simply by enhancing LP→PD synaptic strength. These results show that modulation of the strength and timing of a synaptic input can differentially affect the synapse's efficacy in the network.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.