ArticleCold Spring Harbor symposia on quantitative biology2010
Chromatin boundaries, insulators, and long-range interactions in the nucleus.
Article in Cold Spring Harbor symposia on quantitative biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Rewiring cancer epigenome: lncRNA as modulator of chromatin architecture and neoplastic transformation.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Review
- Epigenetic silencing directs expression heterogeneity of stably integrated multi-transcript unit genetic circuits.Scientific reports · 2021Article
- Characterization of GJB2 cis-regulatory elements in the DFNB1 locus.Human genetics · 2019Article
- New insights emerge as antibody repertoire diversification meets chromosome conformation.F1000Research · 2019Review
- Entropy gives rise to topologically associating domains.Nucleic acids research · 2016Article
- Differential contribution of cis-regulatory elements to higher order chromatin structure and expression of the CFTR locus.Nucleic acids research · 2016Article
- Cell and Gene Therapy for the Beta-Thalassemias: Advances and Prospects.Human gene therapy · 2016Review
- Chromosomes at Work: Organization of Chromosome Territories in the Interphase Nucleus.Journal of cellular biochemistry · 2016Article
- Genomic discovery of potent chromatin insulators for human gene therapy.Nature biotechnology · 2015Article
- Cell type specific alterations in interchromosomal networks across the cell cycle.PLoS computational biology · 2014Article
- Cycles in spatial and temporal chromosomal organization driven by the circadian clock.Nature structural & molecular biology · 2013Article
- Chromatin structure outside and inside the nucleus.Biopolymers · 2013Article
- Use of transgenic animals in biotechnology: prospects and problems.Acta naturae · 2013Article
- Engraftment potential of adipose tissue-derived human mesenchymal stem cells after transplantation in the fetal rabbit.Stem cells and development · 2012Article
- CTCF occupation of the herpes simplex virus 1 genome is disrupted at early times postreactivation in a transcription-dependent manner.Journal of virology · 2012Article
- Self-organization of domain structures by DNA-loop-extruding enzymes.Nucleic acids research · 2012Article
- Development of gene therapy for thalassemia.Cold Spring Harbor perspectives in medicine · 2012Review
- Zebrafish globin switching occurs in two developmental stages and is controlled by the LCR.Developmental biology · 2012Article
- Exploring massive, genome scale datasets with the GenometriCorr package.PLoS computational biology · 2012Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Within the genome, expressed genes marked by "open" chromatin are often adjacent to silent, heterochromatic regions. There are also regions containing neighboring active genes with different programs of expression. In both cases, DNA sequence elements may function as insulators, either providing barriers that prevent the incursion of heterochromatic signals into open domains or acting to block inappropriate contact between the enhancer of one gene and the promoter of another. The mechanisms associated with insulation are diverse: Enhancer-blocking insulation is largely associated with the ability to stabilize the formation of loop domains within the nucleus. Barrier insulation is often associated with the ability to block propagation of silencing histone modifications. Here, we provide examples of both kinds of insulator action, derived initially from studies of the compound insulator element at the 5' end of the chicken β-globin locus. Such elements appear to have more general regulatory roles in the genome that have been exploited to provide insulator function where necessary to demarcate separate domains within the nucleus.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.