Evidence map›Paper›PMID 21047405›Full record

ArticleBMC research notes2010

EMA - A R package for Easy Microarray data analysis.

Nicolas Servant, Eleonore Gravier, Pierre Gestraud, Cecile Laurent, Caroline Paccard, Anne Biton, Isabel Brito, Jonas Mandel, Bernard Asselain, Emmanuel Barillot and 1 more

Abstract read
In one paragraph

Article in BMC research notes, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

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  4. MSPJ: Discovering potential biomarkers in small gene expression datasetsComputational and structural biotechnology journal · 2022
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  13. Endogenous dendritic cells from the tumor microenvironment support T-ALL growth via IGF1R activation.Proceedings of the National Academy of Sciences of the United States of America · 2016
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nicolas ServantInstitut Curie, Paris F-75248, France. Nicolas.Servant@curie.fr.
Eleonore Gravier
Pierre Gestraud
Cecile Laurent
Caroline Paccard
Anne Biton
Isabel Brito
Jonas Mandel
Bernard Asselain
Emmanuel Barillot
Philippe Hupé

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe increasing number of methodologies and tools currently available to analyse gene expression microarray data can be confusing for non specialist users.

findingsBased on the experience of biostatisticians of Institut Curie, we propose both a clear analysis strategy and a selection of tools to investigate microarray gene expression data. The most usual and relevant existing R functions were discussed, validated and gathered in an easy-to-use R package (EMA) devoted to gene expression microarray analysis. These functions were improved for ease of use, enhanced visualisation and better interpretation of results.

conclusionsStrategy and tools proposed in the EMA R package could provide a useful starting point for many microarrays users. EMA is part of Comprehensive R Archive Network and is freely available at http://bioinfo.curie.fr/projects/ema/.

Identifiers

PMID21047405
PMCPMC2987873

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.