ArticleArthritis research & therapy2010
In vivo molecular imaging of experimental joint inflammation by combined (18)F-FDG positron emission tomography and computed tomography.
Article in Arthritis research & therapy, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 63 citations in OpenAlex.
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- Development of an Ultra High Resolution PET Scanner for Imaging Rodent Paws: PawPET.IEEE transactions on radiation and plasma medical sciences · 2018Article
- Development of Diagnostic Techniques for Early Rheumatoid Arthritis Using Positron Emission Tomography with [Molecular imaging and biology · 2017Article
- Automated Quantification of Early Bone Alterations and Pathological Bone Turnover in Experimental Arthritis by in vivo PET/CT Imaging.Scientific reports · 2017Article
- In-vivo quantitative assessment of the therapeutic response in a mouse model of collagen-induced arthritis usingClinical and experimental immunology · 2017Article
- Quantification of arthritic bone degradation by analysis of 3D micro-computed tomography data.Scientific reports · 2017Article
- Preclinical Multimodal Molecular Imaging UsingMolecular imaging · 2017Article
- In vivo quantification of mouse autoimmune arthritis by PET/CT.International journal of rheumatic diseases · 2016Article
- Advances in PET Detection of the Antitumor T Cell Response.Advances in immunology · 2016Review
- Radiation Dosimetry Study of [(89)Zr]rituximab Tracer for Clinical Translation of B cell NHL Imaging using Positron Emission Tomography.Molecular imaging and biology · 2015Article
- Amelioration of experimental arthritis by stroke-induced immunosuppression is independent of Treg cell function.Annals of the rheumatic diseases · 2014Article
- 18 F-Fluoride positron emission tomography/computed tomography for noninvasive in vivo quantification of pathophysiological bone metabolism in experimental murine arthritis.Arthritis research & therapy · 2014Article
- Molecular imaging of rheumatoid arthritis: emerging markers, tools, and techniques.Arthritis research & therapy · 2014Review
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe purpose of this work was to establish and validate combined small animal positron emission tomography - computed tomography (PET/CT) as a new in vivo imaging method for visualisation and quantification of joint inflammation.
methodsSignalling of radioisotope ¹⁸F labelled Fluorodeoxyglucose (¹⁸F-FDG) injected in mice with glucose-6-phosphate isomerase (G6PI)-induced arthritis was analysed by PET/CT. Accumulation of ¹⁸F-FDG in tissue was quantified by PET measurement, whereas high definition CT delivered anatomical information. The fusion of both images revealed in detail spatial and temporal distribution and metabolism of ¹⁸F-FDG.
resultsA distinct ¹⁸F-FDG signal could be measured by PET in carpal and tarsal joints, from mice with early or established arthritis. In contrast, no accumulation of ¹⁸F-FDG was detectable before arthritis onset. Comparison of ¹⁸F-FDG joint uptake with histopathological evaluation revealed a significant correlation of both methods.
conclusionsSmall animal PET/CT using ¹⁸F-FDG is a feasible method for monitoring and, more importantly, quantitative assessment of inflammation in G6PI-arthritis. Since it is possible to perform repeated non-invasive measurements in vivo, not only numbers of animals in preclinical studies can markedly be reduced by this method, but also longitudinal studies come into reach, e. g. for individual flare-up reactions or monitoring therapy response in progressive arthritis.
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