Evidence map›Paper›PMID 21047263›Full record

ReviewAnnual review of genetics2010

The RecQ DNA helicases in DNA repair.

Kara A Bernstein, Serge Gangloff, Rodney Rothstein

Open access · greenAbstract readReview
In one paragraph

Review in Annual review of genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 195 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
195citing papers in PubMed, 1 pooled it
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

195 citing papers in PubMed, 1 synthesis or guideline pooled it, 296 citations in OpenAlex.

  1. Pooled it
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  14. Interstitial telomeric sequences promote gross chromosomal rearrangement via multiple mechanisms.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  15. Article
  16. DDX41: exploring the roles of a versatile helicase.Biochemical Society transactions · 2024
    Review
  17. Article
  18. Article
  19. Article
  20. Article

135 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Kara A BernsteinColumbia University Medical Center, Department of Genetics & Development, New York, New York 10032, USA. kab2142@columbia.edu
Serge Gangloff
Rodney Rothstein
CEA Paris-Saclay - Etablissement de Fontenay-aux-roses · FRColumbia University · USColumbia University Irving Medical Center · US

Funding

Mechanism of spontaneous and DSB-induced repairR37GM050237 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ROTHSTEIN, RODNEY J. · 2005 to 2014
$6.0M
Genetics of the formation of repair &reombination fociR01GM067055 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ROTHSTEIN, RODNEY J. · 2003 to 2014
$4.3M
MECHANISM OF SPONTANEOUS AND DSB-INDUCED REPAIRR01GM050237 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI ROTHSTEIN, RODNEY J. · 1993 to 2016
$3.0M
Mechanistic insights into the SHU complex and Sgs1 in DNA repair and replicationR00GM088413 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BERNSTEIN, KARA A · 2011 to 2013
$772k
Mechanistic insights into the SHU complex and Sgs1 in DNA repair and replicationK99GM088413 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BERNSTEIN, KARA A · 2009 to 2010
$180k
Role of Sgs1, yeast Werner/Bloom homologue in DNA repairF32GM078840 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BERNSTEIN, KARA A · 2006 to 2009
$125k
NIGMS NIH HHS F32 GM078840NIGMS NIH HHS GM078840NIGMS NIH HHS GM088413NIGMS NIH HHS GM50237NIGMS NIH HHS K99 GM088413NIGMS NIH HHS R00 GM088413NIGMS NIH HHS R01 GM050237NIGMS NIH HHS R01 GM067055NIGMS NIH HHS R37 GM050237
6 · The paper itself

Abstract

The RecQ helicases are conserved from bacteria to humans and play a critical role in genome stability. In humans, loss of RecQ gene function is associated with cancer predisposition and/or premature aging. Recent experiments have shown that the RecQ helicases function during distinct steps during DNA repair; DNA end resection, displacement-loop (D-loop) processing, branch migration, and resolution of double Holliday junctions (dHJs). RecQ function in these different processing steps has important implications for its role in repair of double-strand breaks (DSBs) that occur during DNA replication and meiosis, as well as at specific genomic loci such as telomeres.

Indexed as

DNA RepairBacteriaDiseaseGenomic InstabilityHumansRecQ HelicasesRecQ Helicases

Identifiers

PMID21047263
PMCPMC4038414
OpenAlexW2127392515

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.