ArticleNeurourology and urodynamics2011
Urothelial beta-3 adrenergic receptors in the rat bladder.
Article in Neurourology and urodynamics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 55 citations in OpenAlex.
- Pathophysiology of Overactive Bladder and Pharmacologic Treatments Including β3-Adrenoceptor Agonists -Basic Research Perspectives.International neurourology journal · 2024Article
- Inside the Biology of the β3-Adrenoceptor.Biomolecules · 2024Review
- Treating Lower Urinary Tract Symptoms in Older Adults: Intravesical Options.Drugs & aging · 2023Review
- Mirabegron and solifenacin are effective for the management of the increased urinary frequency induced by psychological stress in female mice.Scientific reports · 2022Article
- The effect of amino acids on the bladder cycle: a concise review.Amino acids · 2022Review
- Transient receptor potential vanilloid type 4 (TRPV4) in urinary bladder structure and function.Current topics in membranes · 2022Review
- Sophisticated regulation of micturition: review of basic neurourology.Journal of exercise rehabilitation · 2021Review
- Additive effects of intravenous and intravesical application of vibegron, a βNaunyn-Schmiedeberg's archives of pharmacology · 2020Article
- The Inhibitory Mechanism on Acetylcholine-Induced Contraction of Bladder Smooth Muscle in the Streptozotocin-Induced Diabetic Rat.Biomolecules & therapeutics · 2019Article
- The change of signaling pathway on the electrical stimulated contraction in streptozotocin-induced bladder dysfunction of rats.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2018Article
- Modulation of lower urinary tract smooth muscle contraction and relaxation by the urothelium.Naunyn-Schmiedeberg's archives of pharmacology · 2018Review
- Clinical use of the β3 adrenoceptor agonist mirabegron in patients with overactive bladder syndrome.Therapeutic advances in urology · 2015Review
- Neural control of the lower urinary tract.Comprehensive Physiology · 2015Review
- Rat β₃-adrenoceptor protein expression: antibody validation and distribution in rat gastrointestinal and urogenital tissues.Naunyn-Schmiedeberg's archives of pharmacology · 2014Article
- A functional analysis of the influence of β3-adrenoceptors on the rat micturition cycle.The Journal of pharmacology and experimental therapeutics · 2013Article
- Urothelial signaling.Physiological reviews · 2013Review
- Pharmacological profile of β3-adrenoceptor agonists in clinical development for the treatment of overactive bladder syndrome.Naunyn-Schmiedeberg's archives of pharmacology · 2013Article
- Common theme for drugs effective in overactive bladder treatment: inhibition of afferent signaling from the bladder.International journal of urology : official journal of the Japanese Urological Association · 2013Review
- Evidence for the role of mast cells in colon-bladder cross organ sensitization.Autonomic neuroscience : basic & clinical · 2013Article
- Specificity evaluation of antibodies against human β3-adrenoceptors.Naunyn-Schmiedeberg's archives of pharmacology · 2012Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
aimsTo investigate the distribution of beta-3 adrenergic receptors (β(3)ARs) in the rat bladder and to examine the contribution of urothelial β(3)ARs to agonist-induced suppression of bladder reflexes and relaxation of smooth muscle.
methodsBladder tissue was collected from 8- to 10-month old female SD rats. In some samples, the urothelium was surgically separated from the smooth muscle. The expression and localization of βAR mRNA and β(3)AR protein were determined using RT-PCR and immunohistochemistry. Contractile responses to the specific β(3)AR agonists TAK-677 and BRL37344 were measured in bladder strips with or without the urothelium. The contribution of urothelial β(3)ARs to the micturition reflex was assessed in continuous cystometry in urethane anesthetized rats using intravesical delivery of β(3)AR agonists.
resultsRT-PCR detected mRNA of all βARs in urothelium and smooth muscle. Immunostaining detected β(3)ARs throughout the urothelium, in the smooth muscle, myofibroblast-like cells, and in the peripheral nerves. Ovariectomy did not change the distribution of β(3)ARs in any bladder structure. Intravesical administration of TAK-677 and BRL37344 (1-5 × 10(-4) M) decreased voiding frequency and amplitude of bladder contractions. In bladder strips in vitro both β(3)AR agonists (10(-12) to 10(-4) M) relaxed the smooth muscle in a concentration-dependent manner to the same extent in strips with and without the urothelium.
conclusionsIn addition to their presence in bladder smooth muscle, β(3)ARs are present in the urothelium where their activation may alter reflex voiding via release of factor(s) that act on non-myocyte structures including the afferent and/or efferent nerves to influence bladder contractility.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.