ArticleBehavior genetics2011
Pleiotropic effects of DCDC2 and DYX1C1 genes on language and mathematics traits in nuclear families of developmental dyslexia.
Article in Behavior genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- A systematic review and meta-analysis of imaging genetics studies of specific reading disorder.Cognitive neuropsychology · 2021Pooled it
- Replication study in Chinese population and meta-analysis supports association of the 11q23 locus with colorectal cancer.PloS one · 2012Pooled it
- An assessment of gene-by-gene interactions as a tool to unfold missing heritability in dyslexia.Human genetics · 2015Trial
- New chromosome-scale genomes provide insights into marine adaptations of sea snakes (Hydrophis: Elapidae).BMC biology · 2023Article
- The Polygenic Nature and Complex Genetic Architecture of Specific Learning Disorder.Brain sciences · 2021Review
- Identification of Phonology-Related Genes and Functional Characterization of Broca's and Wernicke's Regions in Language and Learning Disorders.Frontiers in neuroscience · 2021Article
- The Mediation Role of Dynamic Multisensory Processing Using Molecular Genetic Data in Dyslexia.Brain sciences · 2020Article
- The role of READ1 and KIAA0319 genetic variations in developmental dyslexia: testing main and interactive effects.Journal of human genetics · 2017Article
- DCDC2 gene polymorphisms are associated with developmental dyslexia in Chinese Uyghur children.Neural regeneration research · 2017Article
- Multiple Causal Links Between Magnocellular-Dorsal Pathway Deficit and Developmental Dyslexia.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- Mutation of the Dyslexia-Associated Gene Dcdc2 Enhances Glutamatergic Synaptic Transmission Between Layer 4 Neurons in Mouse Neocortex.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- Association of DCDC2 Polymorphisms with Normal Variations in Reading Abilities in a Chinese Population.PloS one · 2016Article
- The role of DCDC2 genetic variants and low socioeconomic status in vulnerability to attention problems.European child & adolescent psychiatry · 2015Article
- KIAA0319 and ROBO1: evidence on association with reading and pleiotropic effects on language and mathematics abilities in developmental dyslexia.Journal of human genetics · 2014Article
- Knockdown of the candidate dyslexia susceptibility gene homolog dyx1c1 in rodents: effects on auditory processing, visual attention, and cortical and thalamic anatomy.Developmental neuroscience · 2013Article
- Mathematics is differentially related to reading comprehension and word decoding: Evidence from a genetically-sensitive design.Journal of educational psychology · 2012Article
- Approach to epigenetic analysis in language disorders.Journal of neurodevelopmental disorders · 2011Article
- Dcdc2 knockout mice display exacerbated developmental disruptions following knockdown of doublecortin.Neuroscience · 2011Article
- DCDC2, KIAA0319 and CMIP are associated with reading-related traits.Biological psychiatry · 2011Article
- Moving closer to a public health model of language and learning disabilities: the role of genetics and the search for etiologies.Behavior genetics · 2011Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Converging evidence indicates that developmental problems in oral language and mathematics can predate or co-occur with developmental dyslexia (DD). Substantial genetic correlations have been found between language, mathematics and reading traits, independent of the method of sampling. We tested for association of variants of two DD susceptibility genes, DCDC2 and DYX1C1, in nuclear families ascertained through a proband with DD using concurrent measurements of language and mathematics in both probands and siblings by the Quantitative Transmission Disequilibrium Test. Evidence for significant associations was found between DCDC2 and 'Numerical Facts' (p value = 0.02, with 85 informative families, genetic effect = 0.57) and between 'Mental Calculation' and DYX1C1 markers -3GA (p value = 0.05, with 40 informative families, genetic effect = -0.67) and 1249GT (p value = 0.02, with 49 informative families, genetic effect = -0.65). No statistically significant associations were found between DCDC2 or DYX1C1 and language phenotypes. Both DCDC2 and DYX1C1 DD susceptibility genes appear to have a pleiotropic role on mathematics but not language phenotypes.
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