Evidence map›Paper›PMID 21045784›Full record

ReviewNature reviews. Cardiology2011

The changing epidemiology of congenital heart disease.

Teun van der Bom, A Carla Zomer, Aeilko H Zwinderman, Folkert J Meijboom, Berto J Bouma, Barbara J M Mulder

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Cardiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02409706 (Micronutrient Deficiencies in Children and Infants With Congenital Heart Diseases), which is not on this map. Cited by 342 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
342citing papers in PubMed, 10 pooled it
10.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02409706 completednot on this mapstarted 2014, after this paper: background citation

Micronutrient Deficiencies in Children and Infants With Congenital Heart Diseases (CHD) Admitted for Cardiac Surgery: A Proof-of-concept Study

TypeobservationalSponsorNHS Greater Glasgow and ClydeRan2014 to 2016Enrolled50ConditionsHeart Defects, Congenital
3 · Its place in the literature

Who cites it

342 citing papers in PubMed, 10 syntheses or guidelines pooled it, 750 citations in OpenAlex.

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  14. A bibliometric analysis of medication studies in congenital heart disease.International journal of cardiology. Congenital heart disease · 2026
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282 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Teun van der BomDepartment of Cardiology, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
A Carla Zomer
Aeilko H Zwinderman
Folkert J Meijboom
Berto J Bouma
Barbara J M Mulder
Academic Medical Center · NLUniversity Medical Center Utrecht · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Congenital heart disease is the most common congenital disorder in newborns. Advances in cardiovascular medicine and surgery have enabled most patients to reach adulthood. Unfortunately, prolonged survival has been achieved at a cost, as many patients suffer late complications, of which heart failure and arrhythmias are the most prominent. Accordingly, these patients need frequent follow-up by physicians with specific knowledge in the field of congenital heart disease. However, planning of care for this population is difficult, because the number of patients currently living with congenital heart disease is difficult to measure. Birth prevalence estimates vary widely according to different studies, and survival rates have not been well recorded. Consequently, the prevalence of congenital heart disease is unclear, with estimates exceeding the number of patients currently seen in cardiology clinics. New developments continue to influence the size of the population of patients with congenital heart disease. Prenatal screening has led to increased rates of termination of pregnancy. Improved management of complications has changed the time and mode of death caused by congenital heart disease. Several genetic and environmental factors have been shown to be involved in the etiology of congenital heart disease, although this knowledge has not yet led to the implementation of preventative measures. In this Review, we give an overview of the etiology, birth prevalence, current prevalence, mortality, and complications of congenital heart disease.

Indexed as

AdolescentAdultCardiac Surgical ProceduresChildChild, PreschoolContinuity of Patient CareHeart Defects, CongenitalHumansInfantInfant, NewbornPrevalenceReoperationRisk AssessmentRisk FactorsSurvival AnalysisSurvival Rate

Identifiers

PMID21045784
OpenAlexW1971320336

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.