ArticleCornea2011
Tear film volume and protein analysis in full-term newborn infants.
Article in Cornea, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Lactoferrin Concentration in Human Tears and Ocular Diseases: A Meta-Analysis.Investigative ophthalmology & visual science · 2020Pooled it
- Optimizing instilled drug delivery: a scoping review of microdrops in ophthalmology.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- NanoLC-timsTOF-Assisted Analysis of Glycated Albumin in Diabetes-Affected Plasma and Tears.Journal of the American Society for Mass Spectrometry · 2024Article
- A Review of Emerging Tear Proteomics Research on the Ocular Surface in Ocular Allergy.Biology · 2022Review
- Ophthalmia neonatorum as the presenting sign of SARS-CoV-2.Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2021Article
- Critical role of mass spectrometry proteomics in tear biomarker discovery for multifactorial ocular diseases (Review).International journal of molecular medicine · 2021Review
- SARS-CoV-2 and the Eye: A Relationship for a Possible Prognostic Tool in COVID-19 Patients.Clinical ophthalmology (Auckland, N.Z.) · 2021Review
- Meibum lipid hydrocarbon chain branching and rheology after hematopoietic stem cell transplantation.Biochemistry and biophysics reports · 2020Article
- Effects of Lipid Saturation on the Surface Properties of Human Meibum Films.International journal of molecular sciences · 2018Article
- Tear protein analysis in presumed congenital alacrima.Clinical ophthalmology (Auckland, N.Z.) · 2018Article
- Formulations for children: problems and solutions.British journal of clinical pharmacology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
purposeTo investigate infant tear film secretion and protein profile, and to compare major tear proteins, such as immunoglobulin A, lactoferrin, and lysozyme, with those of adult controls.
methodsTears were collected, with a cellulose rod, from 40 healthy infants (19 female infants and 21 male infants, gestational duration: 39.71 ± 1.27 weeks) within 48 hours of birth and 22 adults (10 female infants and 12 male infants, mean age: 24.95 ± 3.63 years). A second collection was obtained from 14 of the infants (8 female infants and 6 male infants, postnatal age: 7.76 ± 6.14 weeks). The tear volume was measured, and protein in the samples was analyzed by Bradford assay and gel electrophoresis.
resultsMedian tear volume (interquartile range) was 0.5 μL (0.6-2 μL) for newborn infants, 2.5 μL (1.4-7.75 μL) for these infants at an older age, and 6 μL (2.73-12.75 μL) in adults (P < 0.001, Kruskall-Wallis test). Immunoglobulin A concentration was significantly lower in newborns (P < 0.001, analysis of variance). Lipocalin was present in 36% of the newborn tear samples, whereas serum albumin was found in 86%. Mean protein concentration (μg/μL ± SD) was 10.95 ± 5.51 in the newborns, 12.93 ± 3.99 in the older infants, and 13.04 ± 3.46 in the adults (P > 0.5, analysis of variance).
conclusionsThis is the first study reporting an investigation of unstimulated infant tears, using a noninvasive collection method. Tear protein content demonstrated that the infant tear film is different to that in adults.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.