ArticleAnalytical cellular pathology (Amsterdam)2010
Gene copy number variation in male breast cancer by aCGH.
Article in Analytical cellular pathology (Amsterdam), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 0 citations in OpenAlex.
- Genetic Landscape of Male Breast Cancer.Cancers · 2021Review
- Does copy number variation of APOL1 gene affect the susceptibility to focal segmental glomerulosclerosis?Renal failure · 2017Article
- Genome methylation patterns in male breast cancer - Identification of an epitype with hypermethylation of polycomb target genes.Molecular oncology · 2015Article
- Chromosome 17 copy number changes in male breast cancer.Cellular oncology (Dordrecht, Netherlands) · 2015Article
- The landscape of candidate driver genes differs between male and female breast cancer.PloS one · 2013Article
- Oncogene amplification in male breast cancer: analysis by multiplex ligation-dependent probe amplification.Breast cancer research and treatment · 2012Article
- Gene expression profiling of primary male breast cancers reveals two unique subgroups and identifies N-acetyltransferase-1 (NAT1) as a novel prognostic biomarker.Breast cancer research : BCR · 2012Article
- Article
- Inherited and acquired alterations in development of breast cancer.The application of clinical genetics · 2011Article
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10 authors at 3 institutions in 1 country.
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Abstract
backgroundMale breast cancer (MBC) is a rare disease and little is known about its etiopathogenesis. Array comparative genomic hybridization (aCGH) provides a method to quantitatively measure the changes of DNA copy number and to map them directly onto the complete linear genome sequences. The aim of this study was to investigate DNA imbalances by aCGH and compare them with a female breast cancer dataset.
methodsWe used Agilent Human Genome CGH Microarray Kit 44B and 44K to compare genomic alterations in 25 male breast cancer tissues studied at NCC of Bari and 16 female breast cancer deposited with the Gene Expression Omnibus (GSE12659). Data analysis was performed with Nexus Copy Number 5.0 software.
resultsAll the 25 male and 16 female breast cancer samples displayed some chromosomal instability (110.93 alterations per patient in female, 69 in male). However, male samples presented a lower frequency of genetic alterations both in terms of loss and gains.
conclusionaCGH is an effective tool for analysis of cytogenetic aberrations in MBC, which involves different biological processes than female. Male most significant altered regions contained genes involved in cell communication, cell division and immunological response, while female cell-cell junction maintenance, regulation of transcription and neuron development.
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