ReviewAmerican journal of physiology. Endocrinology and metabolism2011
Neonatal programming of innate immune function.
Review in American journal of physiology. Endocrinology and metabolism, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- Maternal immune activation during the lactational period alters offspring behavior, reproductive development, and immune function in mice.Hormones and behavior · 2025Article
- Maternal immune activation during the lactational period alters offspring behavior, reproductive development, and immune function in mice.bioRxiv : the preprint server for biology · 2025Article
- Acute postnatal inflammation alters adult microglial responses to LPS that are sex-, region- and timing of postnatal inflammation-dependent.Journal of neuroinflammation · 2024Article
- Acute Postnatal Inflammation Alters Adult Microglial Responses to LPS that Are Sex-, Region- and Timing of Postnatal Inflammation-Dependent.Research square · 2024Article
- Macrophage memories of early-life injury drive neonatal nociceptive priming.Cell reports · 2024Article
- Does month of birth influence colorectal cancer prognosis?Langenbeck's archives of surgery · 2023Observational
- Developmental impact of peripheral injury on neuroimmune signaling.Brain, behavior, and immunity · 2023Review
- Melatonin Administration to Pregnant Ewes for Coccidiosis Control in Their Offspring.Animals : an open access journal from MDPI · 2023Article
- Maternal Macro- and Micronutrient Intake During Pregnancy: Does It Affect Allergic Predisposition in Offspring?Immunology and allergy clinics of North America · 2023Review
- Association of Melatonin Administration in Pregnant Ewes with Growth, Redox Status and Immunity of Their Offspring.Animals : an open access journal from MDPI · 2021Article
- Impact of inflammation on developing respiratory control networks: rhythm generation, chemoreception and plasticity.Respiratory physiology & neurobiology · 2020Review
- The effect of early burn injury on sensitivity to future painful stimuli in dairy heifers.PloS one · 2020Article
- One bout of neonatal inflammation impairs adult respiratory motor plasticity in male and female rats.eLife · 2019Article
- Development of Asthma in Inner-City Children: Possible Roles of MAIT Cells and Variation in the Home Environment.Journal of immunology (Baltimore, Md. : 1950) · 2018Observational
- The impact of inflammation on respiratory plasticity.Experimental neurology · 2017Review
- Environmental Enteropathy: Elusive but Significant Subclinical Abnormalities in Developing Countries.EBioMedicine · 2016Review
- Inflammatory insults and mental health consequences: does timing matter when it comes to depression?Psychological medicine · 2016Article
- Maternal pregnancy weight gain and cord blood iron status are associated with eosinophilia in infancy.Journal of perinatology : official journal of the California Perinatal Association · 2015Observational
- Maternal Deprivation of Lewis Rat Pups Increases the Severity of Experi-mental Periodontitis in Adulthood.The open dentistry journal · 2015Article
- Biochemical, histopathological and morphological profiling of a rat model of early immune stimulation: relation to psychopathology.PloS one · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The early life environment can be crucial in influencing the development of an animal's long-term physiology. There is now much evidence to suggest that perinatal challenges to an animal's immune system will result in changes in adult rat behavior, physiology, and molecular pathways following a single inflammatory event during development caused by the bacterial endotoxin lipopolysaccharide (LPS). In particular, it is now apparent that neonatal LPS administration can influence the adult neuroimmune response to a second LPS challenge through hypothalamic-pituitary-adrenal axis modifications, some of which are caused by alterations in peripheral prostaglandin synthesis. These pronounced changes are accompanied by a variety of alterations in a number of disparate aspects of endocrine physiology, with significant implications for the health and well-being of the adult animal. In this review, we discuss the newly elucidated mechanisms by which neonatal immune challenge can permanently alter an animal's endocrine and metabolic physiology and the implications this has for various disease states.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.