ArticleCancer prevention research (Philadelphia, Pa.)2010
Black raspberries inhibit intestinal tumorigenesis in apc1638+/- and Muc2-/- mouse models of colorectal cancer.
Article in Cancer prevention research (Philadelphia, Pa.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- Dose-Dependent Increases in Ellagitannin Metabolites as Biomarkers of Intake in Humans Consuming Standardized Black Raspberry Food Products Designed for Clinical Trials.Molecular nutrition & food research · 2020Trial
- Application of a low polyphenol or low ellagitannin dietary intervention and its impact on ellagitannin metabolism in men.Molecular nutrition & food research · 2017Trial
- Plasma cytokines as potential response indicators to dietary freeze-dried black raspberries in colorectal cancer patients.Nutrition and cancer · 2012Trial
- Randomized phase II trial of lyophilized strawberries in patients with dysplastic precancerous lesions of the esophagus.Cancer prevention research (Philadelphia, Pa.) · 2012Trial
- Evaluation of the Content of Micro- and Macroelements in Raspberries Depending on the Species, Cultivar Variety, and Geographical Environment.Nutrients · 2023Article
- Modification of Diet to Reduce the Stemness and Tumorigenicity of Murine and Human Intestinal Cells.Molecular nutrition & food research · 2022Article
- Unripe Black Raspberry (Foods (Basel, Switzerland) · 2020Article
- Article
- Metabolite Profiling of the Gut Microbiome in Mice with Dietary Administration of Black Raspberries.ACS omega · 2020Article
- Effects of Black Raspberries and Their Constituents on Rat Prostate Carcinogenesis and Human Prostate Cancer Cell Growth In Vitro.Nutrition and cancer · 2020Article
- Chemopreventive Effects of Strawberry and Black Raspberry on Colorectal Cancer in Inflammatory Bowel Disease.Nutrients · 2019Review
- Clinical significance of the correlation between PLCE 1 and PRKCA in esophageal inflammation and esophageal carcinoma.Oncotarget · 2017Article
- Protective Role of Dietary Berries in Cancer.Antioxidants (Basel, Switzerland) · 2016Review
- Article
- Chemopreventive and Therapeutic Effects of Edible Berries: A Focus on Colon Cancer Prevention and Treatment.Molecules (Basel, Switzerland) · 2016Review
- Mulberry fruit prevents LPS-induced NF-κB/pERK/MAPK signals in macrophages and suppresses acute colitis and colorectal tumorigenesis in mice.Scientific reports · 2015Article
- Black raspberries suppress colonic adenoma development in ApcMin/+ mice: relation to metabolite profiles.Carcinogenesis · 2015Article
- Anti inflammatory and anti angiogenic effect of black raspberry extract on human esophageal and intestinal microvascular endothelial cells.Microvascular research · 2015Article
- Anthocyanin-rich fractions from red raspberries attenuate inflammation in both RAW264.7 macrophages and a mouse model of colitis.Scientific reports · 2014Article
- Chemoprevention of esophageal cancer with black raspberries, their component anthocyanins, and a major anthocyanin metabolite, protocatechuic acid.Cancer prevention research (Philadelphia, Pa.) · 2014Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Freeze-dried black raspberries (BRB) produce chemopreventive effects in a rat model of colon carcinogenesis; however, the mechanisms of inhibition were not determined. Herein, we used two mouse models of human colorectal cancer to determine if dietary BRBs would inhibit colorectal tumor development and to investigate the underlying mechanisms. We found that a 12-week feeding of BRBs significantly inhibited intestinal tumor formation in both models; reducing tumor incidence by 45% and tumor multiplicity by 60% in Apc1638+/- mice and tumor incidence and multiplicity by 50% in Muc2-/- mice. Mechanistic studies revealed that BRBs inhibit tumor development in Apc1638+/- mice by suppressing β-catenin signaling and in Muc2-/- mice by reducing chronic inflammation. Intestinal cell proliferation was inhibited by BRBs in both animal models; however, the extent of mucus cell differentiation was not changed in either model. Collectively, our data suggest that BRBs are highly effective in preventing intestinal tumor development in both Apc1638+/- and Muc2-/- mice through targeting multiple signaling pathways.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.