ReviewCancer prevention research (Philadelphia, Pa.)2010
Deploying mouse models of pancreatic cancer for chemoprevention studies.
Review in Cancer prevention research (Philadelphia, Pa.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Ion Channel Targeting with Antibodies and Antibody Fragments for Cancer Diagnosis.Antibodies (Basel, Switzerland) · 2019Review
- Safety and Efficacy of AAV Retrograde Pancreatic Ductal Gene Delivery in Normal and Pancreatic Cancer Mice.Molecular therapy. Methods & clinical development · 2018Article
- Translational pancreatic cancer research: A comparative study on patient-derived xenograft models.World journal of gastroenterology · 2018Article
- Article
- Optimizing mouse models for precision cancer prevention.Nature reviews. Cancer · 2016Review
- Pancreatic cancer organotypics: High throughput, preclinical models for pharmacological agent evaluation.World journal of gastroenterology · 2014Review
- Rac1b negatively regulates TGF-β1-induced cell motility in pancreatic ductal epithelial cells by suppressing Smad signalling.Oncotarget · 2014Article
- Rebuilding cancer metastasis in the mouse.Molecular oncology · 2013Review
- Activated K-Ras and INK4a/Arf deficiency promote aggressiveness of pancreatic cancer by induction of EMT consistent with cancer stem cell phenotype.Journal of cellular physiology · 2013Article
- The combination of the histone deacetylase inhibitor vorinostat and synthetic triterpenoids reduces tumorigenesis in mouse models of cancer.Carcinogenesis · 2013Article
- New biomarkers and targets in pancreatic cancer and their application to treatment.Nature reviews. Gastroenterology & hepatology · 2012Review
- The role of inflammatory cells in fostering pancreatic cancer cell growth and invasion.Frontiers in physiology · 2012Article
- Experimental animal models of pancreatic carcinogenesis for prevention studies and their relevance to human disease.Cancers · 2011Article
- Article
- A concise review on the current understanding of pancreatic cancer stem cells.Journal of cancer stem cell researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
With the advent of mouse models that recapitulate the cellular and molecular pathology of pancreatic neoplasia and cancer, it is now feasible to recruit and deploy these models for the evaluation of various chemopreventive and/or anticancer regimens. The highly lethal nature of pancreatic ductal adenocarcinoma (PDAC) makes multiple areas of research a priority, including assessment of compounds that prevent or suppress the development of early lesions that can transform into PDAC. Currently, there are over a dozen models available, which range from homogeneous preneoplastic lesions with remarkable similarity to human pancreatic intraepithelial neoplasms to models with a more heterogeneous population of lesions including cystic papillary and mucinous lesions. The molecular features of these models may also vary in a manner comparable with the differences observed in lesion morphology, and so, navigating the route of model selection is not trivial. Yet, arming the community of cancer investigators with a repertoire of models and the guidance to select relevant models that fit their research themes promises to produce findings that will have clinical relevance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.