ArticleProceedings of the National Academy of Sciences of the United States of America2010
Molecular basis of coiled-coil oligomerization-state specificity.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Opposing Roles of CREPT and p15RS in Tumorigenesis via Differential Regulation of Wnt Signaling.Cancers · 2026Article
- Orthogonal Tri-Modular Coiled-Coil Assembly for Programmable Multi-Cargo Display on Escherichia coli Nissle 1917.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Sudden death-associated KCNH2 variants exert opposing effects on a nuclear subdomain of the cardiac potassium channel hERG1.The Journal of biological chemistry · 2026Article
- Biomolecular condensation of ERC1 recruits ATG8 and NBR1 to drive autophagosome formation for plant heat tolerance.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Sudden Death-AssociatedbioRxiv : the preprint server for biology · 2025Article
- Dynamic ensembles of SARS-CoV-2 N-protein reveal head-to-head coiled-coil-driven oligomerization and phase separation.Nucleic acids research · 2025Article
- PICK1 links KIBRA and AMPA receptor subunit GluA2 in coiled-coil-driven supramolecular complexes.The Journal of biological chemistry · 2025Article
- Preformed mincle dimers stabilized by an interchain disulfide bond in the neck region.Glycobiology · 2024Article
- Autophagy receptor NDP52 alters DNA conformation to modulate RNA polymerase II transcription.Nature communications · 2023Article
- Nuclear condensates of YAP fusion proteins alter transcription to drive ependymoma tumourigenesis.Nature cell biology · 2023Article
- Physical tuning of galectin-3 signaling.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.Journal of molecular biology · 2020Article
- Molecular recognition of human islet amyloid polypeptide assembly by selective oligomerization of thioflavin T.Science advances · 2020Article
- Supramolecular Assemblies of Peptides or Nucleopeptides for Gene Delivery.Theranostics · 2019Review
- Locally anchoring enzymes to tissues via extracellular glycan recognition.Nature communications · 2018Article
- Article
- Design considerations in coiled-coil fusion constructs for the structural determination of a problematic region of the human cardiac myosin rod.Journal of structural biology · 2017Article
- Ubiquitin enzymes in the regulation of immune responses.Critical reviews in biochemistry and molecular biology · 2017Review
- The Structure and Topology of α-Helical Coiled Coils.Sub-cellular biochemistry · 2017Review
- Screening for protein-protein interactions using Förster resonance energy transfer (FRET) and fluorescence lifetime imaging microscopy (FLIM).Scientific reports · 2016Article
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Authors and funding
9 authors.
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Abstract
Coiled coils are extensively and successfully used nowadays to rationally design multistranded structures for applications, including basic research, biotechnology, nanotechnology, materials science, and medicine. The wide range of applications as well as the important functions these structures play in almost all biological processes highlight the need for a detailed understanding of the factors that control coiled-coil folding and oligomerization. Here, we address the important and unresolved question why the presence of particular oligomerization-state determinants within a coiled coil does frequently not correlate with its topology. We found an unexpected, general link between coiled-coil oligomerization-state specificity and trigger sequences, elements that are indispensable for coiled-coil formation. By using the archetype coiled-coil domain of the yeast transcriptional activator GCN4 as a model system, we show that well-established trimer-specific oligomerization-state determinants switch the peptide's topology from a dimer to a trimer only when inserted into the trigger sequence. We successfully confirmed our results in two other, unrelated coiled-coil dimers, ATF1 and cortexillin-1. We furthermore show that multiple topology determinants can coexist in the same trigger sequence, revealing a delicate balance of the resulting oligomerization state by position-dependent forces. Our experimental results should significantly improve the prediction of the oligomerization state of coiled coils. They therefore should have major implications for the rational design of coiled coils and consequently many applications using these popular oligomerization domains.
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