ArticleThe Journal of biological chemistry2011
Heart-type fatty acid-binding protein is essential for efficient brown adipose tissue fatty acid oxidation and cold tolerance.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
64 citing papers in PubMed, 1 synthesis or guideline pooled it, 112 citations in OpenAlex.
- Thermogenic Differentiation of Human Adipocyte Precursors in Culture: A Systematic Review.Cells · 2025Pooled it
- An RNA thermogenic therapy to preserve lean mass and enhance metabolic health during GLP-1 weight loss.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Comparison of Fatty Acid Binding Protein 3 and Ankle Brachial Index for Predicting Peripheral Artery Disease Outcomes.Biomolecules · 2026Article
- DENND5B disruption results in reduced body fat and increased intestinal fatty acid oxidation by activation of autophagy.Journal of lipid research · 2026Article
- Light up heart-type fatty acid binding protein (FABP3) with a novel fluorine-18 labelled selective FABP3 ligand.EJNMMI research · 2024Article
- Article
- X chromosome dosage drives statin-induced dysglycemia and mitochondrial dysfunction.Nature communications · 2024Article
- Cross-species transcriptomics identifies obesity associated genes between human and mouse studies.Journal of translational medicine · 2024Article
- Blood biomarker changes following therapeutic hypothermia in ischemic stroke.Brain and behavior · 2023Article
- Non-shivering thermogenesis is differentially regulated during the hibernation season in Arctic ground squirrels.Frontiers in physiology · 2023Article
- The Role of Fatty Acid Binding Protein 3 in Cardiovascular Diseases.Biomedicines · 2022Review
- Fatty Acid-Binding Proteins in Psoriasis-A Review.Metabolites · 2022Review
- PET/MRI-Evaluated Activation of Brown Adipose Tissue via Cold Exposure Impacts Lipid Metabolism.Metabolites · 2022Article
- Genomic expansion of Aldh1a1 protects beavers against high metabolic aldehydes from lipid oxidation.Cell reports · 2021Article
- Sex-specific genetic regulation of adipose mitochondria and metabolic syndrome by Ndufv2.Nature metabolism · 2021Article
- Antisense oligonucleotide-mediated knockdown of Mpzl3 attenuates the negative metabolic effects of diet-induced obesity in mice.Physiological reports · 2021Article
- FABP3 Deficiency Exacerbates Metabolic Derangement in Cardiac Hypertrophy and Heart Failure via PPARα Pathway.Frontiers in cardiovascular medicine · 2021Article
- Lipid Transport in Brown Adipocyte Thermogenesis.Frontiers in physiology · 2021Review
- Both proliferation and lipogenesis of brown adipocytes contribute to postnatal brown adipose tissue growth in mice.Scientific reports · 2020Article
- Induction of UCP1 and thermogenesis by a small molecule via AKAP1/PKA modulation.The Journal of biological chemistry · 2020Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Brown adipose tissue has a central role in thermogenesis to maintain body temperature through energy dissipation in small mammals and has recently been verified to function in adult humans as well. Here, we demonstrate that the heart-type fatty acid-binding protein, FABP3, is essential for cold tolerance and efficient fatty acid oxidation in mouse brown adipose tissue, despite the abundant expression of adipose-type fatty acid-binding protein, FABP4 (also known as aP2). Fabp3(-/-) mice exhibit extreme cold sensitivity despite induction of uncoupling and oxidative genes and hydrolysis of brown adipose tissue lipid stores. However, using FABP3 gain- and loss-of-function approaches in brown adipocytes, we detected a correlation between FABP3 levels and the utilization of exogenous fatty acids. Thus, Fabp3(-/-) brown adipocytes fail to oxidize exogenously supplied fatty acids, whereas enhanced Fabp3 expression promotes more efficient oxidation. These results suggest that FABP3 levels are a determinant of fatty acid oxidation efficiency by brown adipose tissue and that FABP3 represents a potential target for modulation of energy dissipation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.