ReviewAlzheimer's & dementia : the journal of the Alzheimer's Association2010
Dependence as a unifying construct in defining Alzheimer's disease severity.
Review in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- Cognitive rehabilitation for people with mild to moderate dementia.The Cochrane database of systematic reviews · 2023Pooled it
- Convergent validity of EQ-5D with core outcomes in dementia: a systematic review.Health and quality of life outcomes · 2022Pooled it
- Health state values for use in the economic evaluation of treatments for Alzheimer's disease.Drugs & aging · 2012Pooled it
- The Alzheimer's Disease Cooperative Study - Activities of Daily Living dependence score: revision and validation of an algorithm evaluating patient dependence across the spectrum of AD severity.The journal of prevention of Alzheimer's disease · 2025Trial
- Psychometric properties of the Dependence Scale in large randomized clinical trials of patients with mild and moderate Alzheimer's disease.American journal of Alzheimer's disease and other dementias · 2014Trial
- Alzheimer's Disease and Oral Health from Clinical Challenges to Interdisciplinary Care: A Narrative Review.Journal of clinical medicine · 2025Review
- General practitioner and practice nurses perspectives on implementation of the 75+ health assessment: Implications for dementia care and well-being.Journal of advanced nursing · 2025Article
- The Role of Social Support for Depressive Symptoms in Dementia: A Four-Year Longitudinal Study.Innovation in aging · 2025Article
- Facilitators and barriers of help-seeking for persons with dementia in Asia-findings from a qualitative study of informal caregivers.Frontiers in public health · 2024Article
- Trajectories of cognitive and perceived functional decline in people with dementia: Findings from the IDEAL programme.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Resilience in caregivers of people with mild-to-moderate dementia: findings from the IDEAL cohort.BMC geriatrics · 2023Article
- Move Your Body toward Healthy Aging: Potential Neuroprotective Mechanisms of Irisin in Alzheimer's Disease.International journal of molecular sciences · 2023Review
- Rural-urban disparities in preventive breast and cervical cancer screening among women with early-onset dementia.BMC women's health · 2023Article
- Self-perceived care needs and quality of life in people with cognitive impairment during routine care at home: cross-sectional results of the interventional study.BMC geriatrics · 2023Article
- Article
- Validation of the German Montreal-Cognitive-Assessment-H for hearing-impaired.Frontiers in aging neuroscience · 2023Article
- Impact of behavioral and psychological symptoms of Alzheimer's disease on caregiver outcomes.Scientific reports · 2022Article
- The use of formal care for dementia from a professional perspective: a scoping review.BMC health services research · 2022Article
- The Impact of Agitation in Dementia on Caregivers: A Real-World Survey.Journal of Alzheimer's disease : JAD · 2022Article
- Stephapierrines A-H, new tetrahydroprotoberberine and aporphine alkaloids from the tubers ofRSC advances · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 10 institutions in 3 countries.
Funding
Abstract
This article reviews measures of Alzheimer's disease (AD) progression in relation to patient dependence and offers a unifying conceptual framework for dependence in AD. Clinicians typically characterize AD by symptomatic impairments in three domains: cognition, function, and behavior. From a patient's perspective, changes in these domains, individually and in concert, ultimately lead to increased dependence and loss of autonomy. Examples of dependence in AD range from a need for reminders (early AD) to requiring safety supervision and assistance with basic functions (late AD). Published literature has focused on the clinical domains as somewhat separate constructs and has given limited attention to the concept of patient dependence as a descriptor of AD progression. This article presents the concept of dependence on others for care needs as a potential method for translating the effect of changes in cognition, function, and behavior into a more holistic, transparent description of AD progression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.