Evidence map›Paper›PMID 21044697›Full record

ArticleJournal of biomedical informatics2011

Towards a framework for developing semantic relatedness reference standards.

Serguei V S Pakhomov, Ted Pedersen, Bridget McInnes, Genevieve B Melton, Alexander Ruggieri, Christopher G Chute

Abstract read
In one paragraph

Article in Journal of biomedical informatics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
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  4. Improving medical term embeddings using UMLS Metathesaurus.BMC medical informatics and decision making · 2022
    Article
  5. Article
  6. Article
  7. Article
  8. Article
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  11. Using word embeddings to improve the privacy of clinical notes.Journal of the American Medical Informatics Association : JAMIA · 2020
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. U-path: An undirected path-based measure of semantic similarity.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2014
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Serguei V S PakhomovCollege of Pharmacy, University of Minnesota, Twin Cities, Minneapolis, MN 55455, USA. pakh0002@umn.edu
Ted Pedersen
Bridget McInnes
Genevieve B Melton
Alexander Ruggieri
Christopher G Chute

Funding

STANFORD COMPOSITE(RMI)U54HG004028 · NHGRI · STANFORD UNIVERSITY · PI MUSEN, MARK A · 2005 to 2014
$36.2M
RESEARCH TRAINING IN MEDICAL INFORMATICST15LM007041 · NLM · UNIVERSITY OF MINNESOTA TWIN CITIES · PI GATEWOOD, LAEL C. · 1985 to 2007
$3.9M
Sematic Relatedness for Active Medication Safety and Outcomes SurveillanceR01LM009623 · NLM · UNIVERSITY OF MINNESOTA · PI PAKHOMOV, SERGUEI VS · 2008 to 2010
$949k
NHGRI NIH HHS U54 HG004028NLM NIH HHS R01 LM009623NLM NIH HHS T15 LM007041NLM NIH HHS T15 LM07041-19
6 · The paper itself

Abstract

Our objective is to develop a framework for creating reference standards for functional testing of computerized measures of semantic relatedness. Currently, research on computerized approaches to semantic relatedness between biomedical concepts relies on reference standards created for specific purposes using a variety of methods for their analysis. In most cases, these reference standards are not publicly available and the published information provided in manuscripts that evaluate computerized semantic relatedness measurement approaches is not sufficient to reproduce the results. Our proposed framework is based on the experiences of medical informatics and computational linguistics communities and addresses practical and theoretical issues with creating reference standards for semantic relatedness. We demonstrate the use of the framework on a pilot set of 101 medical term pairs rated for semantic relatedness by 13 medical coding experts. While the reliability of this particular reference standard is in the "moderate" range; we show that using clustering and factor analyses offers a data-driven approach to finding systematic differences among raters and identifying groups of potential outliers. We test two ontology-based measures of relatedness and provide both the reference standard containing individual ratings and the R program used to analyze the ratings as open-source. Currently, these resources are intended to be used to reproduce and compare results of studies involving computerized measures of semantic relatedness. Our framework may be extended to the development of reference standards in other research areas in medical informatics including automatic classification, information retrieval from medical records and vocabulary/ontology development.

Indexed as

SemanticsClinical CodingDatabases, FactualMedical InformaticsMedical Records Systems, ComputerizedReference StandardsSoftware

Identifiers

PMID21044697
PMCPMC3063326

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.