ReviewProgress in neuro-psychopharmacology & biological psychiatry2011
Psychomotor retardation in depression: biological underpinnings, measurement, and treatment.
Review in Progress in neuro-psychopharmacology & biological psychiatry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 146 papers, 6 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
146 citing papers in PubMed, 6 syntheses or guidelines pooled it, 377 citations in OpenAlex.
- A systematic review of the prevalence of fatigue in common mental disorders (mood disorders, anxiety disorders, personality disorders, and trauma and stressor related disorders).BMC psychiatry · 2026Pooled it
- A Systematic Review of Antidepressants and Psychotherapy Commonly Used in the Treatment of Late Life Depression for Their Effects on Cognition.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2025Pooled it
- Unraveling the mystery of white matter in depression: A translational perspective on recent advances.Brain and behavior · 2022Pooled it
- Actigraphically measured psychomotor slowing in depression: systematic review and meta-analysis.Psychological medicine · 2022Pooled it
- Maternal depressive symptoms and maternal child-directed speech: A systematic review.Journal of affective disorders · 2022Pooled it
- Psychoradiologic abnormalities of white matter in patients with bipolar disorder: diffusion tensor imaging studies using tract-based spatial statisticsJournal of psychiatry & neuroscience : JPN · 2019Pooled it
- Inhibitory neurotransmission in frontostriatal circuitry: implications for psychomotor and vegetative symptoms in depressive episodes.BMC psychiatry · 2026Trial
- Embodied cognition driven Qigong: a cross-sectional study and a pilot randomized controlled trial on managing depression and preventing relapse in substance dependence.Frontiers in public health · 2024Trial
- Tai chi improves psychoemotional state, cognition, and motor learning in older adults during the COVID-19 pandemic.Experimental gerontology · 2021Trial
- Mechanisms of Exercise Training in Ameliorating Cognitive Function in Patients With Depression: A Narrative Review of Molecular Targets and Clinical Prescriptions.European journal of sport science · 2026Review
- Identifying Mood Instability and Circadian Rest-Activity Patterns Using Digital Remote Monitoring and Actigraphy in Participants at Risk for Bipolar Disorder.Bipolar disorders · 2026Article
- Network localization of brain structural and functional alterations induced by electroconvulsive therapy for depression.Translational psychiatry · 2026Article
- Electroconvulsive therapy in an older patient with recurrent major depressive disorder and a permanent pacemaker: A case report.PCN reports : psychiatry and clinical neurosciences · 2026Article
- Rotarod training reverses corticosterone-induced motor deficits via oligodendrocyte lineage cell modulation.Neural regeneration research · 2026Article
- Variability in self-reported depression symptomology and associated behavioral markers in digital phenotyping.Scientific reports · 2026Article
- The association between spatiotemporal coupling of default mode network and behaviors is specifically modulated by peripheral inflammation in major depressive disorder.BMC psychiatry · 2026Article
- A Conversational Platform (Okaya) for Multimodal Digital Biomarkers of Fatigue, Cognition, and Mental Health: Feasibility Observational Study.JMIR formative research · 2026Observational
- Differences in gait biomechanics during level walking between chronic stroke patients with and without depression.Scientific reports · 2026Article
- Reduced striatal dopamine transmission as a transdiagnostic substrate of psychomotor retardation.Brain : a journal of neurology · 2026Review
- Generalizable stratification based on thalamo-somatomotor functional connectivity predicts responses to antidepressants in patients with depression.Molecular psychiatry · 2026Article
86 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Psychomotor retardation is a long established component of depression that can have significant clinical and therapeutic implications for treatment. Due to its negative impact on overall function in depressed patients, we review its biological correlates, optimal methods of measurement, and relevance in the context of therapeutic interventions. The aim of the paper is to provide a synthesis of the literature on psychomotor retardation in depression with the goal of enhanced awareness for clinicians and researchers. Increased knowledge and understanding of psychomotor retardation in major depressive disorder may lead to further research and better informed diagnosis in regards to psychomotor retardation. Manifestations of psychomotor retardation include slowed speech, decreased movement, and impaired cognitive function. It is common in patients with melancholic depression and those with psychotic features. Biological correlates may include abnormalities in the basal ganglia and dopaminergic pathways. Neurophysiologic tools such as neuroimaging and transcranial magnetic stimulation may play a role in the study of this symptom in the future. At present, there are three objective scales to evaluate psychomotor retardation severity. Studies examining the impact of psychomotor retardation on clinical outcome have found differential results. However, available evidence suggests that depressed patients with psychomotor retardation may respond well to electroconvulsive therapy (ECT). Current literature regarding antidepressants is inconclusive, though tricyclic antidepressants may be considered for treatment of patients with psychomotor retardation. Future work examining this objective aspect of major depressive disorder (MDD) is essential. This could further elucidate the biological underpinnings of depression and optimize its treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.