ArticleBiophysical journal2010
A multiscale model of the electrophysiological basis of the human electrogastrogram.
Article in Biophysical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 66 citations in OpenAlex.
- Gastric slow-wave morphology in health and disease.Digestive diseases and sciences · 2026Article
- [A New Paradigm in Diagnosing Functional Gastroduodenal Disorders: High-Resolution Electrogastrography].The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2024Review
- Principles and clinical methods of body surface gastric mapping: Technical review.Neurogastroenterology and motility · 2023Review
- A novel scalable electrode array and system for non-invasively assessing gastric function using flexible electronics.Neurogastroenterology and motility · 2023Article
- Relationships between serum electrolyte concentrations and ileus: A joint clinical and mathematical modeling study.Physiological reports · 2021Article
- Electrogastrography for psychophysiological research: Practical considerations, analysis pipeline, and normative data in a large sample.Psychophysiology · 2020Review
- Polygonally Meshed Dipole Model Simulation of the Electrical Field Produced by the Stomach and Intestines.Computational and mathematical methods in medicine · 2020Article
- Temporary Gastric Stimulation in Patients With Gastroparesis Symptoms: Low-Resolution Mapping Multiple Versus Single Mucosal Lead Electrograms.Gastroenterology research · 2019Article
- Multiscale modeling methods in biomechanics.Wiley interdisciplinary reviews. Systems biology and medicine · 2017Review
- High-Resolution Electrogastrogram: A Novel, Noninvasive Method for Determining Gastric Slow-Wave Direction and Speed.IEEE transactions on bio-medical engineering · 2017Article
- Progress in Mathematical Modeling of Gastrointestinal Slow Wave Abnormalities.Frontiers in physiology · 2017Review
- A theoretical study of the initiation, maintenance and termination of gastric slow wave re-entry.Mathematical medicine and biology : a journal of the IMA · 2015Article
- A Multiscale Tridomain Model for Simulating Bioelectric Gastric Pacing.IEEE transactions on bio-medical engineering · 2015Article
- A Stochastic Algorithm for Generating Realistic Virtual Interstitial Cell of Cajal Networks.IEEE transactions on bio-medical engineering · 2015Article
- Gastric arrhythmias in gastroparesis: low- and high-resolution mapping of gastric electrical activity.Gastroenterology clinics of North America · 2015Review
- Slow wave conduction patterns in the stomach: from Waller's foundations to current challenges.Acta physiologica (Oxford, England) · 2015Review
- Recent progress in gastric arrhythmia: pathophysiology, clinical significance and future horizons.Clinical and experimental pharmacology & physiology · 2014Article
- A theoretical analysis of the electrogastrogram (EGG).Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2014Article
- Gastric emptying and duodenal motility upon intake of a liquid meal with monosodium glutamate in healthy subjects.Physiological reports · 2014Article
- Reconstruction of normal and abnormal gastric electrical sources using a potential based inverse method.Physiological measurement · 2013Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The motility of the stomach is coordinated by an electrical activity termed "slow waves", and slow-wave dysrhythmias contribute to motility disorders. One major method for clinically evaluating gastric dysrhythmias has been electrogastrography (EGG); however, the clinical utility of EGG is limited partly due to the uncertainty regarding its electrophysiological basis. In this study, a multiscale model of gastric slow waves was generated from a biophysically based continuum description of cellular electrical events, coupled with a subject-specific human stomach model and high-resolution electrical mapping data. The model was then applied using a forward-modeling approach, within an anatomical torso model, to define how slow wave activity summates to generate the EGG potentials. The simulated EGG potentials were shown to be spatially varying in amplitude (0.27-0.33 mV) and duration (9.2-15.3 s), and the sources of this variance were quantified with respect to the activation timings of the underlying slow wave activity. This model constitutes an improved theory of the electrophysiological basis of the EGG, and offers a framework for optimizing the placement of EGG electrodes, and for interpreting the EGG changes occurring in disease states.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.