ArticleBiophysical journal2010
Effect of sensor domain mutations on the properties of voltage-gated ion channels: molecular dynamics studies of the potassium channel Kv1.2.
Article in Biophysical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- A Model Framework for Ion Channels with Selectivity Filters Based on Non-Equilibrium Thermodynamics.Entropy (Basel, Switzerland) · 2025Article
- Anionic omega currents from single countercharge mutants in the voltage-sensing domain of Ci-VSP.The Journal of general physiology · 2024Article
- Identification of Proteins Involved in Cell Membrane Permeabilization by Nanosecond Electric Pulses (nsEP).International journal of molecular sciences · 2023Article
- Nanosecond Pulsed Electric Field (nsPEF): Opening the Biotechnological Pandora's Box.International journal of molecular sciences · 2022Review
- Structural Mechanism of ω-Currents in a Mutated Kv7.2 Voltage Sensor Domain from Molecular Dynamics Simulations.Journal of chemical information and modeling · 2021Article
- Multiscale modeling shows that dielectric differences make NaV channels faster than KV channels.The Journal of general physiology · 2021Article
- The Voltage-Dependent Deactivation of the KvAP Channel Involves the Breakage of Its S4 Helix.Frontiers in molecular biosciences · 2020Article
- Voltage-dependent gating in K channels: experimental results and quantitative models.Pflugers Archiv : European journal of physiology · 2020Review
- Sites and Functional Consequence of Alkylphenol Anesthetic Binding to Kv1.2 Channels.Molecular neurobiology · 2018Article
- A New Cardiac Channelopathy: From Clinical Phenotypes to Molecular Mechanisms Associated With NaFrontiers in cardiovascular medicine · 2018Review
- Mechanisms Responsible for ω-Pore Currents in CaBiophysical journal · 2017Article
- Atomistic Modeling of Ion Conduction through the Voltage-Sensing Domain of the Shaker KThe journal of physical chemistry. B · 2017Article
- A recurrent mutation in KCNA2 as a novel cause of hereditary spastic paraplegia and ataxia.Annals of neurology · 2016Article
- Voltage-Gated Potassium Channels: A Structural Examination of Selectivity and Gating.Cold Spring Harbor perspectives in biology · 2016Review
- Theoretical and simulation studies on voltage-gated sodium channels.Protein & cell · 2015Review
- Gating pore currents are defects in common with two Nav1.5 mutations in patients with mixed arrhythmias and dilated cardiomyopathy.The Journal of general physiology · 2015Article
- Gating pore currents, a new pathological mechanism underlying cardiac arrhythmias associated with dilated cardiomyopathy.Channels (Austin, Tex.) · 2015Article
- Domain and interdomain energetics underlying gating in Shaker-type Kv channels.Biophysical journal · 2014Article
- Mechanisms of activation of voltage-gated potassium channels.Acta naturae · 2014Article
- An emerging consensus on voltage-dependent gating from computational modeling and molecular dynamics simulations.The Journal of general physiology · 2012Article
Corrections and comments
- Erratum issued
- Erratum issued
Authors and funding
4 authors.
Funding
Abstract
The effects on the structural and functional properties of the Kv1.2 voltage-gated ion channel, caused by selective mutation of voltage sensor domain residues, have been investigated using classical molecular dynamics simulations. Following experiments that have identified mutations of voltage-gated ion channels involved in state-dependent omega currents, we observe for both the open and closed conformations of the Kv1.2 that specific mutations of S4 gating-charge residues destabilize the electrostatic network between helices of the voltage sensor domain, resulting in the formation of hydrophilic pathways linking the intra- and extracellular media. When such mutant channels are subject to transmembrane potentials, they conduct cations via these so-called "omega pores." This study provides therefore further insight into the molecular mechanisms that lead to omega currents, which have been linked to certain channelopathies.
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