ArticleBMC bioinformatics2010
Feasibility of incorporating genomic knowledge into electronic medical records for pharmacogenomic clinical decision support.
Article in BMC bioinformatics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinical decision support for genetically guided personalized medicine: a systematic review.Journal of the American Medical Informatics Association : JAMIAPooled it
- Advancing precision public health using human genomics: examples from the field and future research opportunities.Genome medicine · 2021Article
- Clinical Genome Data Model (cGDM) provides Interactive Clinical Decision Support for Precision Medicine.Scientific reports · 2020Article
- A Model Information Management Plan for Molecular Pathology Sequence Data Using Standards: From Sequencer to Electronic Health Record.The Journal of molecular diagnostics : JMD · 2019Article
- Comparing cytochrome P450 pharmacogenetic information available on United States drug labels and European Union Summaries of Product Characteristics.The pharmacogenomics journal · 2017Article
- Genomic decision support needs in pediatric primary care.Journal of the American Medical Informatics Association : JAMIA · 2017Article
- Incorporating Pharmacogenomics into Health Information Technology, Electronic Health Record and Decision Support System: An Overview.Journal of medical systems · 2017Review
- Physician perspectives of CYP2C19 and clopidogrel drug-gene interaction active clinical decision support alerts.International journal of medical informatics · 2016Article
- Integrating "big data" into surgical practice.Surgery · 2016Review
- An Extended SNOMED CT Concept Model for Observations in Molecular Genetics.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2016Article
- The future of murine sepsis and trauma research models.Journal of leukocyte biology · 2015Review
- Privacy in the Genomic Era.ACM computing surveys · 2015Article
- Making pharmacogenomic-based prescribing alerts more effective: A scenario-based pilot study with physicians.Journal of biomedical informatics · 2015Article
- Pragmatic and Ethical Challenges of Incorporating the Genome into the Electronic Medical Record.Current genetic medicine reports · 2014Article
- Pharmacogenetics and immunosuppressive drugs in solid organ transplantation.Nature reviews. Nephrology · 2014Review
- Pediatric critical care: grand challenges for a glowing future.Frontiers in pediatrics · 2014Article
- Pharmacogenomic knowledge gaps and educational resource needs among physicians in selected specialties.Pharmacogenomics and personalized medicine · 2014Article
- A survey of informatics approaches to whole-exome and whole-genome clinical reporting in the electronic health record.Genetics in medicine : official journal of the American College of Medical Genetics · 2013Article
- Personalized medicine: challenges and opportunities for translational bioinformatics.Personalized medicine · 2013Article
- Scientific challenges and implementation barriers to translation of pharmacogenomics in clinical practice.ISRN pharmacology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
In pursuing personalized medicine, pharmacogenomic (PGx) knowledge may help guide prescribing drugs based on a person's genotype. Here we evaluate the feasibility of incorporating PGx knowledge, combined with clinical data, to support clinical decision-making by: 1) analyzing clinically relevant knowledge contained in PGx knowledge resources; 2) evaluating the feasibility of a rule-based framework to support formal representation of clinically relevant knowledge contained in PGx knowledge resources; and, 3) evaluating the ability of an electronic medical record/electronic health record (EMR/EHR) to provide computable forms of clinical data needed for PGx clinical decision support. Findings suggest that the PharmGKB is a good source for PGx knowledge to supplement information contained in FDA approved drug labels. Furthermore, we found that with supporting knowledge (e.g. IF age <18 THEN patient is a child), sufficient clinical data exists in University of Washington's EMR systems to support 50% of PGx knowledge contained in drug labels that could be expressed as rules.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.