ArticleBMC medical genetics2010
Chromosomal abnormalities in spontaneous abortion after assisted reproductive treatment.
Article in BMC medical genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06762704 (A Non-Invasive Artificial Intelligence Model for the Prediction of Human Blastocyst Ploidy), which is not on this map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Non-Invasive Artificial Intelligence Model for the Prediction of Human Blastocyst Ploidy: a Multi-Center, Prospective, Non-Randomized Validation Study
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.
- Risk of chromosomal abnormalities in early spontaneous abortion after assisted reproductive technology: a meta-analysis.PloS one · 2013Pooled it
- Comparison of chromosomal abnormality rates in ICSI for non-male factor and spontaneous conception.Journal of assisted reproduction and genetics · 2012Trial
- Conventional in vitro fertilization enhances preimplantation genetic testing for aneuploidy outcomes in couples with non-male factor infertility.Scientific reports · 2025Article
- Non-invasively predicting euploidy in human blastocysts via quantitative 3D morphology measurement: a retrospective cohort study.Reproductive biology and endocrinology : RB&E · 2024Article
- Intracytoplasmic sperm injection versus conventional in vitro fertilization in unexplained infertility.F&S reports · 2024Article
- Genomic aspects in reproductive medicine.Clinical and experimental reproductive medicine · 2024Article
- Impact of blastocyst grading and blastocyst biopsy dates on the clinical outcomes of patients undergoing preimplantation genetic testing.Frontiers in endocrinology · 2024Article
- Chromosomal abnormalities in recurrent pregnancy loss and its association with clinical characteristics.Journal of assisted reproduction and genetics · 2023Article
- Chromosomal analysis of 262 miscarried conceptuses: a retrospective study.BMC pregnancy and childbirth · 2022Article
- Non-invasive Prenatal Testing in Pregnancies Following Assisted Reproduction.Current genomics · 2022Review
- The de novo aberration rate of prenatal karyotype was comparable between 1496 fetuses conceived via IVF/ICSI and 1396 fetuses from natural conception.Journal of assisted reproduction and genetics · 2022Article
- Case Report: Prenatal Identification of aFrontiers in genetics · 2022Article
- Article
- ALWAYS ICSI? A SWOT analysis.Journal of assisted reproduction and genetics · 2020Review
- Detection of chromosomal abnormalities in spontaneous miscarriage by low‑coverage next‑generation sequencing.Molecular medicine reports · 2020Article
- Effect of assisted reproductive technology on the molecular karyotype of missed abortion tissues.Bioscience reports · 2018Article
- Application of chromosomal microarray analysis in products of miscarriage.Molecular cytogenetics · 2018Article
- Differences in pregnancy outcomes in donor egg frozen embryo transfer (FET) cycles following preimplantation genetic screening (PGS): a single center retrospective study.Journal of assisted reproduction and genetics · 2017Article
- Cytogenetic Analysis for Suspected Chromosomal Abnormalities; A Five Years Experience.Journal of clinical and diagnostic research : JCDR · 2016Article
- The freezing method of cleavage stage embryos has no impact on the weight of the newborns.Journal of assisted reproduction and genetics · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe evaluated cytogenetic results occurring with first trimester pregnancy loss, and assessed the type and frequency of chromosomal abnormalities after assisted reproductive treatment (ART) and compared them with a control group. We also compared the rate of chromosomal abnormalities according to infertility causes in ICSI group.
methodsA retrospective cohort analysis was made of all patients who were referred to the Genetics Laboratory of Fertility Center of CHA Gangnam Medical Center from 2005 to 2009 because of clinical abortion with a subsequent dilation and evacuation (D&E) performed, and patients were grouped by type of conception as follows: conventional IVF (in vitro fertilization) (n = 114), ICSI (intracytoplasmic sperm injection) (n = 140), and control (natural conception or intrauterine insemination [IUI]) (n = 128). Statistical analysis was performed using SPSS software.
resultsA total 406 specimens were referred to laboratory, ten abortuses were excluded, and in 14 cases, we did not get any spontaneous metaphase, chromosomal constitutions of 382 specimens were successfully obtained with conventional cytogenetic methods. Overall, 52.62% of the miscarriages were found to be cytogenetically abnormal among all patients, the frequency was 48.4% in the control group, 54.3% of miscarriages after ICSI and 55.3% after conventional IVF (p = 0.503). The most prevalent abnormalities were autosomal trisomy, however, nine (11.69%) sex chromosome aneuploidy were noted in the ICSI group vs. four (6.45%) and two (3.23%) cases in the conventional IVF group and control group. We compared chromosomal abnormalities of miscarriages after ICSI according to infertility factor. 55.71% underwent ICSI due to male factors, 44.29% due to non-male factors. ICSI group having male factors showed significantly higher risk of chromosomal abnormalities than ICSI group having non-male factors (65.8% vs. 34.2%, p = 0.009, odds ratio = 1.529, 95% CI = 1.092-2.141).
conclusionsThere is no increased risk of chromosomal abnormalities due to ART was found with the exception of a greater number of sex chromosomal abnormalities in the ICSI group with male factor infertility. Therefore, these alterations could be correlated with the underlying parental risk of abnormalities and not with the ICSI procedure itself.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.