ArticleMicrocirculation (New York, N.Y. : 1994)2010
Orthopedic trauma-induced pulmonary injury in the obese Zucker rat.
Article in Microcirculation (New York, N.Y. : 1994), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03671746 (Inflammatory Response to Trauma - Does Early Cytokine Modulation Improve Patient Outcome), which is not on this map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Inflammatory Response to Trauma - Does Early Cytokine Modulation Improve Patient Outcome
Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- A rat model of orthopedic injury-induced hypercoagulability and fibrinolytic shutdown.The journal of trauma and acute care surgery · 2020Article
- Early treatment with GLP-1 after severe trauma preserves renal function in obese Zucker rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- OBESITY AND CRITICAL ILLNESS: INSIGHTS FROM ANIMAL MODELS.Shock (Augusta, Ga.) · 2016Review
- Hyperglycemia-Mediated Oxidative Stress Increases Pulmonary Vascular Permeability.Microcirculation (New York, N.Y. : 1994) · 2016Article
- Distinct temporal phases of microvascular rarefaction in skeletal muscle of obese Zucker rats.American journal of physiology. Heart and circulatory physiology · 2014Article
- Inhibition of NADPH oxidase prevents acute lung injury in obese rats following severe trauma.American journal of physiology. Heart and circulatory physiology · 2014Article
- A novel experimental model of orthopedic trauma with acute kidney injury in obese Zucker rats.Physiological reports · 2013Article
- Impact of the body mass on complications and outcome in multiple trauma patients: what does the weight weigh?Mediators of inflammation · 2013Article
- Impaired blood pressure recovery to hemorrhage in obese Zucker rats with orthopedic trauma.American journal of physiology. Heart and circulatory physiology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
objectiveObese subjects with orthopedic trauma exhibit increased inflammation and an increased risk of pulmonary edema. Prostaglandin E(2) (PGE(2) ) production is elevated during inflammation and associated with increased vascular permeability. We hypothesize that pulmonary edema in obesity following orthopedic trauma is due to elevated PGE(2) and resultant increases in pulmonary permeability.
methodsOrthopedic trauma was induced in both hindlimbs in lean (LZ) and obese Zucker rats (OZ). On the following day, plasma interleukin-6 (IL-6) and PGE(2) levels, pulmonary edema, and pulmonary gas exchange capability were compared between groups: LZ, OZ, LZ with trauma (LZT), and OZ with trauma (OZT). Vascular permeability in isolated lungs was measured in LZ and OZ before and after application of PGE(2) .
resultsAs compared with the other groups, the OZT exhibited elevated plasma IL-6 and PGE(2) levels, increased lung wet/dry weight ratio and bronchoalveolar protein concentration, and an impaired pulmonary gas exchange. Indomethacin treatment normalized plasma PGE(2) levels and pulmonary edema. Basal pulmonary permeability in isolated lungs was higher in OZ than LZ, with a further increase in permeability following treatment with PGE(2) .
conclusionsThese results suggest that pulmonary edema in OZ following orthopedic trauma is due to an elevated PGE(2) and resultant increases in pulmonary permeability.
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Registered trials
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