Evidence map›Paper›PMID 21042891›Full record

ArticleClinical orthopaedics and related research2011

Vascular abnormalities correlate with decreased soft tissue volumes in idiopathic clubfoot.

Laura J Merrill, Christina A Gurnett, Marilyn Siegel, Sushil Sonavane, Matthew B Dobbs

Abstract readMulticenter Study
In one paragraph

Article in Clinical orthopaedics and related research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
  2. Alternative Methods of Fixation for Anterior Tibialis Transfer in Residual Clubfoot Deformity.Journal of the Pediatric Orthopaedic Society of North America · 2024
    Article
  3. Article
  4. Article
  5. Congenital talipes equinovarus: A literature review.Annals of medicine and surgery (2012) · 2022
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Genetics of clubfoot.Journal of pediatric orthopedics. Part B · 2012
    Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Laura J MerrillDepartment of Orthopedic Surgery, Washington University School of Medicine, 1 Children's Place, Suite 4S60, St Louis, MO 63110, USA.
Christina A Gurnett
Marilyn Siegel
Sushil Sonavane
Matthew B Dobbs
Washington University in St. Louis · USMallinckrodt (United States) · US

Funding

Washington University Institute of Clinical and Translational Sciences (UL1)UL1RR024992 · NCRR · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2007 to 2011
$45.4M
INTERDISCIPLINARY RESEARCH CAREERS IN WOMEN'S HEALTHK12HD001459 · NICHD · WASHINGTON UNIVERSITY · PI SEMENKOVICH, CLAY F. · 2000 to 2014
$6.9M
The Role of the Osteoblast Secretome in Bone FormationP30AR057235 · NIAMS · WASHINGTON UNIVERSITY · PI SWARNKAR, GAURAV · 2009 to 2018
$5.7M
Washington University Institute of Clinical and Translational Sciences (TL1)TL1RR024995 · NCRR · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2007 to 2011
$2.3M
NCRR NIH HHS TL1 RR024995NCRR NIH HHS UL1 RR024992NIAMS NIH HHS P30 AR057235NICHD NIH HHS K12 HD001459
6 · The paper itself

Abstract

backgroundLower extremity vascular anomalies have been described for patients with clubfoot but few imaging studies have investigated effects on soft tissues such as fat and muscle. To make these assessments we need noninvasive, noncontrast agents to more safely image children. QUESTIONS/PURPOSES: We describe a novel noninvasive imaging protocol to identify vascular and soft tissue abnormalities in the lower limbs of patients with clubfoot and determine whether these abnormalities are present in patients who had recurrent clubfoot. PATIENTS AND

methodsThree-dimensional noncontrast-enhanced MR angiography was used to identify vascular, bone, and soft tissue abnormalities in patients with clubfoot. We determined whether these abnormalities were more common in patients who had experienced recurrent clubfoot.

resultsFour patients with isolated unilateral clubfoot had arterial anomalies in the clubfoot limb. All patients had less muscle volume in the affected limb, and nine of 11 patients (82%) had less subcutaneous fat, with a mean difference of 0.56 cm(3) ± 0.36 cm(3) (range, 0.08-1.12 cm(3)). Vascular anomalies and decreased fat and muscle volumes were present in all three patients with recurrent clubfoot.

conclusionsWe found a high frequency of vascular and soft tissue anomalies in the affected limbs of patients with unilateral clubfoot that may correlate with response to treatment.

Indexed as

Magnetic Resonance AngiographyAdultChildClubfootFemaleHumansImaging, Three-DimensionalLower ExtremityMaleMiddle AgedMissouriMuscle, SkeletalOrthopedic ProceduresRecurrenceSubcutaneous FatTreatment Outcome

Identifiers

PMID21042891
PMCPMC3069258
OpenAlexW2087987364

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.