ReviewCellular and molecular life sciences : CMLS2011
Neural mechanisms of operant conditioning and learning-induced behavioral plasticity in Aplysia.
Review in Cellular and molecular life sciences : CMLS, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 71 citations in OpenAlex.
- Predictive modeling of medical waste and a proposal to improve segregation in a peruvian hospital.Scientific reports · 2026Article
- Advancing Stroke Recovery Through Operant Conditioning of Corticomuscular Coherence.Restorative neurology and neuroscience · 2026Review
- Cognition from genes to ecology: individual differences incognition and its potential role in a social network.Animal cognition · 2025Review
- Sodium-mediated plateau potentials in an identified decisional neuron contribute to feeding-related motor pattern genesis inFrontiers in neural circuits · 2023Article
- Specific Plasticity Loci and Their Synergism Mediate Operant Conditioning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Neuronal population activity dynamics reveal a low-dimensional signature of operant learning in Aplysia.Communications biology · 2022Article
- Rest Is Required to Learn an Appetitively-Reinforced Operant Task inFrontiers in behavioral neuroscience · 2021Article
- Dopamine as a Multifunctional Neurotransmitter in Gastropod Molluscs: An Evolutionary Hypothesis.The Biological bulletin · 2020Review
- Computational model of the distributed representation of operant reward memory: combinatoric engagement of intrinsic and synaptic plasticity mechanisms.Learning & memory (Cold Spring Harbor, N.Y.) · 2020Article
- Does the Punishment Fit the Crime (and Immune System)? A Potential Role for the Immune System in Regulating Punishment Sensitivity.Frontiers in psychology · 2020Article
- Visual Contrast Modulates Operant Learning Responses in Larval Zebrafish.Frontiers in behavioral neuroscience · 2019Article
- Differential role of calpain-dependent protein cleavage in intermediate and long-term operant memory in Aplysia.Neurobiology of learning and memory · 2017Article
- Appetitive Olfactory Learning and Long-Term Associative Memory inFrontiers in behavioral neuroscience · 2017Article
- Article
- Phylogenetic and individual variation in gastropod central pattern generators.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2015Review
- Operant conditioning: a minimal components requirement in artificial spiking neurons designed for bio-inspired robot's controller.Frontiers in neurorobotics · 2014Article
- Molluscan cells in culture: primary cell cultures and cell lines.Canadian journal of zoology · 2013Article
- Effects of aversive stimuli beyond defensive neural circuits: reduced excitability in an identified neuron critical for feeding in Aplysia.Learning & memory (Cold Spring Harbor, N.Y.) · 2012Article
- Rapid and persistent suppression of feeding behavior induced by sensitization training in Aplysia.Learning & memory (Cold Spring Harbor, N.Y.) · 2012Article
- Functional organization and adaptability of a decision-making network in aplysia.Frontiers in neuroscience · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Associative learning in goal-directed behaviors, in contrast to reflexive behaviors, can alter processes of decision-making in the selection of appropriate action and its initiation, thereby enabling animals, including humans, to gain a predictive understanding of their external environment. In the mollusc Aplysia, recent studies on appetitive operant conditioning in which the animal learns about the positive consequences of its behavior have provided insights into this form of associative learning which, although ubiquitous, remains mechanistically poorly understood. The findings support increasing evidence that central circuit- and cell-wide sites other than chemical synaptic connections, including electrical coupling and membrane conductances controlling intrinsic neuronal excitability and underlying voltage-dependent plateauing or oscillatory mechanisms, may serve as the neural substrates for behavioral plasticity resulting from operant conditioning. Aplysia therefore continues to provide a model system for understanding learning and memory formation that enables establishing the neurobiological links between behavioral, network, and cellular levels of analysis.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.