ArticleDevelopment genes and evolution2010
Notch signaling does not regulate segmentation in the honeybee, Apis mellifera.
Article in Development genes and evolution, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Developmental transcriptomics reveals stage-specific immune gene expression profiles in Spodoptera frugiperda.Scientific reports · 2025Article
- Notch Signaling in Insect Development: A Simple Pathway with Diverse Functions.International journal of molecular sciences · 2023Review
- The organizing role of Wnt signaling pathway during arthropod posterior growth.Frontiers in cell and developmental biology · 2022Review
- Early embryonic development of Bombyx.Development genes and evolution · 2021Review
- Delta-Notch signalling in segmentation.Arthropod structure & development · 2017Review
- Ancient role ofHereditas · 2017Article
- Blastoderm segmentation in Oncopeltus fasciatus and the evolution of insect segmentation mechanisms.Proceedings. Biological sciences · 2016Article
- Notch signalling mediates reproductive constraint in the adult worker honeybee.Nature communications · 2016Article
- Gene expression analysis reveals that Delta/Notch signalling is not involved in onychophoran segmentation.Development genes and evolution · 2016Article
- Transcriptome Analysis of Honeybee (Apis Mellifera) Haploid and Diploid Embryos Reveals Early Zygotic Transcription during Cleavage.PloS one · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Notch signaling has been implicated in the segmentation of vertebrates but is not involved in segmentation in Drosophila. Recent evidence, however, implies that Notch signaling regulates segmentation in some Arthropods, including an insect, and that Notch signaling regulated segmentation in the common ancestor of Vertebrates and Arthropods. Notch signaling regulates clock-like formation of segments in both groups, a phenomenon not seen in Drosophila. We present evidence that Notch signaling components are expressed in a pattern implying a role in segmentation in honeybees, where the expression of genes involved in segmentation are modulated in a temporal way. Despite this, pharmacological investigation and RNA interference experiments indicate that Notch signaling does not regulate segmentation in honeybees, but instead regulates patterning within segments after segmentation itself has occurred. Notch signaling thus does not regulate segmentation in holometabolous insects, even when segments appear to form in anterior-posterior sequence.
Indexed as
Identifiers
21042810What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.