ReviewAsian journal of andrology2011
Acrosome reaction: relevance of zona pellucida glycoproteins.
Review in Asian journal of andrology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 65 citations in OpenAlex.
- Molecular interplay between sperm and oocyte: a narrative review.Human reproduction update · 2026Review
- Review
- Diversity of sialic acids and sialoglycoproteins in gametes and at fertilization.Frontiers in cell and developmental biology · 2022Review
- Simulating nature in sperm selection for assisted reproduction.Nature reviews. Urology · 2022Review
- Decoding the role of cytochrome c in metabolism of human spermatozoa by Raman imaging.Frontiers in cell and developmental biology · 2022Article
- New Insights into the Mammalian Egg Zona Pellucida.International journal of molecular sciences · 2021Review
- Potential fertilizer of spermatozoa in porcine epididymal tail post-orchiectomy.Veterinary research forum : an international quarterly journal · 2021Article
- ACRBP (Sp32) is involved in priming sperm for the acrosome reaction and the binding of sperm to the zona pellucida in a porcine model.PloS one · 2021Article
- ZP4 Is Present in Murine Zona Pellucida and Is Not Responsible for the Specific Gamete Interaction.Frontiers in cell and developmental biology · 2020Article
- Failure of complete hatching of ICSI-derived human blastocyst by cell herniation via small slit and insufficient expansion despite ongoing cell proliferation.Journal of assisted reproduction and genetics · 2019Article
- Effect of human ZP3 monoclonal antibody on expression of GDF-9 and number of theca cells in ovary of mice (Journal of Taibah University Medical Sciences · 2018Article
- Gamete activation: basic knowledge and clinical applications.Human reproduction update · 2016Review
- Metabolites involved in cellular communication among human cumulus-oocyte-complex and sperm during in vitro fertilization.Reproductive biology and endocrinology : RB&E · 2015Article
- Network analyses of sperm-egg recognition and binding: ready to rethink fertility mechanisms?Omics : a journal of integrative biology · 2014Article
- TCTEX1D4 interactome in human testis: unraveling the function of dynein light chain in spermatozoa.Omics : a journal of integrative biology · 2014Article
- Fucose, mannose, and β-N-acetylglucosamine glycopolymers initiate the mouse sperm acrosome reaction through convergent signaling pathways.ACS chemical biology · 2014Article
- Is prnt a pseudogene? Identification of ram Prt in testis and ejaculated spermatozoa.PloS one · 2012Article
- Video imaging of the sperm acrosome reaction during in vitro fertilization.Communicative & integrative biology · 2011Article
- Sperm cell biology: current perspectives and future prospects.Asian journal of andrology · 2011Article
- Roles of RNA-binding Proteins and Post-transcriptional Regulation in Driving Male Germ Cell Development in the Mouse.Advances in experimental medicine and biologyArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During mammalian fertilisation, the zona pellucida (ZP) matrix surrounding the oocyte is responsible for the binding of the spermatozoa to the oocyte and induction of the acrosome reaction (AR) in the ZP-bound spermatozoon. The AR is crucial for the penetration of the ZP matrix by spermatozoa. The ZP matrix in mice is composed of three glycoproteins designated ZP1, ZP2 and ZP3, whereas in humans, it is composed of four (ZP1, ZP2, ZP3 and ZP4). ZP3 acts as the putative primary sperm receptor and is responsible for AR induction in mice, whereas in humans (in addition to ZP3), ZP1 and ZP4 also induce the AR. The ability of ZP3 to induce the AR resides in its C-terminal fragment. O-linked glycans are critical for the murine ZP3-mediated AR. However, N-linked glycans of human ZP1, ZP3 and ZP4 have important roles in the induction of the AR. Studies with pharmacological inhibitors showed that the ZP3-induced AR involves the activation of the G(i)-coupled receptor pathway, whereas ZP1- and ZP4-mediated ARs are independent of this pathway. The ZP3-induced AR involves the activation of T-type voltage-operated calcium channels (VOCCs), whereas ZP1- and ZP4-induced ARs involve both T- and L-type VOCCs. To conclude, in mice, ZP3 is primarily responsible for the binding of capacitated spermatozoa to the ZP matrix and induction of the AR, whereas in humans (in addition to ZP3), ZP1 and ZP4 also participate in these stages of fertilisation.
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