ReviewThe Journal of clinical investigation2010
Central modulation of pain.
Review in The Journal of clinical investigation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 512 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
512 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Pharmacological Influences on the R2 Blink Reflex Response in Healthy Participants: A Systematic Review.The European journal of neuroscience · 2026Pooled it
- Music-based interventions for chronic pain management.The Cochrane database of systematic reviews · 2026Pooled it
- The cerebellum in migraine: a narrative review of anatomical, imaging, and clinical evidence.Frontiers in neurology · 2026Pooled it
- Seed-based resting-state connectivity as a neurosignature in fibromyalgia and depression: a narrative systematic review.Frontiers in human neuroscience · 2025Pooled it
- Efficacy and Safety of Agomelatine in Depressed Patients with Diabetes: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2024Pooled it
- An opioid-withholding human laboratory paradigm during opioid agonist treatment for opioid use disorder and chronic pain: Phase- and dose-dependent effects of cannabidiol.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Trial
- Trial
- Trial
- Prolonged continuous theta burst stimulation increases motor corticospinal excitability and intracortical inhibition in patients with neuropathic pain: An exploratory, single-blinded, randomized controlled trial.Neurophysiologie clinique = Clinical neurophysiology · 2023Trial
- Outcomes of a controlled trial with visiting therapy dog teams on pain in adults in an emergency department.PloS one · 2022Trial
- Investigating endogenous pain modulation through pupillometry: can pupil size reflect offset analgesia?Pain reports · 2026Article
- Changes in hormones and experimental pain sensitivity in healthy girls: an exploratory longitudinal pilot study.Pain reports · 2026Article
- Common Mechanisms in Migraine, Migraine-Related Neck Pain, and Low Back Pain: Implications for Treatment.Pain and therapy · 2026Review
- Therapeutic potential of CMPP, a novel maleimide derivative, in a reserpine-induced mouse model of pain-depression dyad.Biochemistry and biophysics reports · 2026Article
- Low-dose morphine and airway sensations in refractory chronic cough: a randomised control trial.ERJ open research · 2026Article
- Structural and Functional Treatment of Persistent Spinal Pain Syndrome Type 2: A Fibrosis-Stratified Network Meta-Analysis of Epidural Adhesiolysis and Neuromodulation.Journal of clinical medicine · 2026Review
- Axillary-pouch capsular thinning after ultrasound-guided hydrodilation in post-stroke adhesive capsulitis: a longitudinal observational study.Journal of ultrasound · 2026Article
- Comorbid Conditions of Ehlers-Danlos Syndromes and Vulvodynia: A Latent Class Analysis.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2026Article
- Neural encoding of pain is robust within but unstable between individuals.PLoS biology · 2026Article
- Classic Psychedelics for Treating Chronic Pain: Mechanism and Clinical Translation.Molecules (Basel, Switzerland) · 2026Review
452 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
It has long been appreciated that the experience of pain is highly variable between individuals. Pain results from activation of sensory receptors specialized to detect actual or impending tissue damage (i.e., nociceptors). However, a direct correlation between activation of nociceptors and the sensory experience of pain is not always apparent. Even in cases in which the severity of injury appears similar, individual pain experiences may vary dramatically. Emotional state, degree of anxiety, attention and distraction, past experiences, memories, and many other factors can either enhance or diminish the pain experience. Here, we review evidence for "top-down" modulatory circuits that profoundly change the sensory experience of pain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.