ReviewThe Journal of clinical investigation2010
Nociceptors: the sensors of the pain pathway.
Review in The Journal of clinical investigation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06030297 (Diode Laser as a Biomarker for Neuropathic Pain of Peripheral Origin.), which is not on this map. Cited by 570 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Diode Laser as a Biomarker for Neuropathic Pain of Peripheral Origin.
Who cites it
570 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Photobiomodulation in chronic pain: a systematic review of randomized clinical trials.Frontiers in integrative neuroscience · 2026Pooled it
- The effect of Jintiange capsules on pain in patients with primary osteoporosis: a systematic review and meta-analysis.BMC musculoskeletal disorders · 2025Pooled it
- Pulsed 830-nm Laser Irradiation Modulates Aδ- and C-Fiber-Mediated Pain Thresholds in Healthy Adults: A Randomized, Sham-Controlled Trial.Lasers in surgery and medicine · 2026Trial
- Perception of first and second pain during offset analgesia.Experimental brain research · 2025Trial
- Clinical Evaluation of the Temperature Dependence of Subcutaneous Injection Experience in Healthy Volunteers.Pharmaceutical research · 2025Trial
- Post-operative pain after root canal preparation with different apical finishing sizes a triple blinded split mouth clinical trial.BMC oral health · 2024Trial
- Can instrumentation kinematics affect postoperative pain and substance P levels? A randomized controlled trial.BMC oral health · 2024Trial
- Effect of multidimensional physiotherapy on non-specific chronic low back pain: a randomized controlled trial.Advances in rheumatology (London, England) · 2023Trial
- Skin hypersensitivity in chronic cough patients: symptom profiles and psychosomatic correlates.Annals of medicine · 2026Article
- Real-time assessment of temperature sensitivity, pain processing, and pain behavior across the lifespan: Integrating stimulus data, contact force, and subjective ratings.Behavior research methods · 2026Article
- Spinal afferent innervation from the left dorsal root ganglia in flat-mounts of whole ventricles of rats: Anterograde tracing.Autonomic neuroscience : basic & clinical · 2026Article
- Cancer-related pain: A bidirectional modulator of cancer progression.Clinical and translational medicine · 2026Review
- Chronic pain in Alzheimer disease and the role of neuroimmune interactions.Pharmacological reviews · 2026Review
- Modelling the memory of unmyelinated axons: Integration of a data-driven approach with physiological memory concept.The Journal of physiology · 2026Article
- Illuminating ongoing pain in mice with novel bioluminescent imaging.The journal of pain · 2026Article
- Beyond Disease Categories: The Adaptive Hierarchical Domain Network (AHDN) for Precision Phenotyping and Personalized Management of Chronic Orofacial Pain.Clinics and practice · 2026Article
- Peripheral Neuropathy in Metabolic Stress.International journal of molecular sciences · 2026Review
- Neuroimmune braking mechanisms in exercise-related musculoskeletal injury: from nociceptors to tissue regeneration.Journal of neuroinflammation · 2026Review
- Article
- Innovative strategies for diabetic peripheral neuropathy: From clinical management to emerging bioengineering solutions.Bioactive materials · 2026Review
510 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Specialized peripheral sensory neurons known as nociceptors alert us to potentially damaging stimuli at the skin by detecting extremes in temperature and pressure and injury-related chemicals, and transducing these stimuli into long-ranging electrical signals that are relayed to higher brain centers. The activation of functionally distinct cutaneous nociceptor populations and the processing of information they convey provide a rich diversity of pain qualities. Current work in this field is providing researchers with a more thorough understanding of nociceptor cell biology at molecular and systems levels and insight that will allow the targeted design of novel pain therapeutics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.