ReviewThe Journal of physiology2011
Acute effects of reactive oxygen and nitrogen species on the contractile function of skeletal muscle.
Review in The Journal of physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers, 3 of them syntheses that pooled it.
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The trial behind it
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Who cites it
94 citing papers in PubMed, 3 syntheses or guidelines pooled it, 168 citations in OpenAlex.
- Pooled it
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- Eccentric Exercise and Muscle Damage: An Introductory Guide.Journal of functional morphology and kinesiology · 2026Review
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- Dissimilar Effects of Selenite and Selenium Nanoparticles on Skeletal Muscle Development Unrelated to GPx1 Activity During Adolescence in Rats.Nutrients · 2025Article
- Comprehensive Insights into Sarcopenia in Dialysis Patients: Mechanisms, Assessment, and Therapeutic Approaches.Medicina (Kaunas, Lithuania) · 2025Review
- Myofiber structure, sarcoplasmic reticulum CaPhysiological reports · 2025Article
- Combined Effects of Spirulina Liquid Extract and Endurance Training on Aerobic Performance and Muscle Metabolism Adaptation in Wistar Rats.Nutrients · 2025Article
- Influence of skeletal muscle heterogeneity on autophagic signaling and response.Autophagy reports · 2025Review
- Mitochondria as Nutritional Targets to Maintain Muscle Health and Physical Function During Ageing.Sports medicine (Auckland, N.Z.) · 2024Review
34 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reactive oxygen and nitrogen species (ROS/RNS) are important for skeletal muscle function under both physiological and pathological conditions. ROS/RNS induce long-term and acute effects and the latter are the focus of the present review. Upon repeated muscle activation both oxygen and nitrogen free radicals likely increase and acutely affect contractile function. Although fluorescent indicators often detect only modest increases in ROS during repeated activation, there are numerous studies showing that manipulations of ROS can affect muscle fatigue development and recovery. Exposure of intact muscle fibres to the oxidant hydrogen peroxide (H(2)O(2)) affects mainly the myofibrillar function, where an initial increase in Ca(2+) sensitivity is followed by a decrease. Experiments on skinned fibres show that these effects can be attributed to H(2)O(2) interacting with glutathione and myoglobin, respectively. The primary RNS, nitric oxide (NO()), may also acutely affect myofibrillar function and decrease the Ca(2+) sensitivity. H(2)O(2) can oxidize the sarcoplasmic reticulum Ca(2+) release channels. This oxidation has a large stimulatory effect on Ca(2+)-induced Ca(2+) release of isolated channels, whereas it has little or no effect on the physiological, action potential-induced Ca(2+) release in skinned and intact muscle fibres. Thus, acute effects of ROS/RNS on muscle function are likely to be mediated by changes in myofibrillar Ca(2+) sensitivity, which can contribute to the development of muscle fatigue or alternatively help counter it.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.