ArticleMolecular and cellular biology2011
Wnt11 promotes cardiomyocyte development by caspase-mediated suppression of canonical Wnt signals.
Article in Molecular and cellular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed, 75 citations in OpenAlex.
- The Roles of Secreted Wnt Ligands in Cancer.International journal of molecular sciences · 2023Review
- A study of the diagnostic value of a modified transthoracic lung ultrasound scoring method in interstitial lung disease.Quantitative imaging in medicine and surgery · 2023Article
- Decrease of Pdzrn3 is required for heart maturation and protects against heart failure.Scientific reports · 2022Article
- Making the head: Caspases in life and death.Frontiers in cell and developmental biology · 2022Review
- Neurogenic Potential of the 18-kDa Mitochondrial Translocator Protein (TSPO) in Pluripotent P19 Stem Cells.Cells · 2021Article
- Heart organoids and tissue models for modeling development and disease.Seminars in cell & developmental biology · 2021Review
- Article
- Caspase dependent apoptosis is required for anterior regeneration in Aeolosoma viride and its related gene expressions are regulated by the Wnt signaling pathway.Scientific reports · 2020Article
- Cell quality control mechanisms maintain stemness and differentiation potential of P19 embryonic carcinoma cells.Autophagy · 2020Article
- Secretome Analysis Performed DuringFrontiers in cell and developmental biology · 2020Article
- The effect of GnRH antagonist cetrorelix on Wnt signaling members in pubertal and adult mouse ovaries.Histochemistry and cell biology · 2019Article
- Genome Wide Meta-Analysis identifies common genetic signatures shared by heart function and Alzheimer's disease.Scientific reports · 2019Article
- Caspase Cleavage of Gelsolin Is an Inductive Cue for Pathologic Cardiac Hypertrophy.Journal of the American Heart Association · 2018Article
- Non-apoptotic Caspase regulation of stem cell properties.Seminars in cell & developmental biology · 2018Review
- Yixin-Shu facilitated cardiac-like differentiation of mesenchymal stem cellsRSC advances · 2018Article
- FZD4 Marks Lateral Plate Mesoderm and Signals with NORRIN to Increase Cardiomyocyte Induction from Pluripotent Stem Cell-Derived Cardiac Progenitors.Stem cell reports · 2018Article
- The Structure and Biological Function of CREG.Frontiers in cell and developmental biology · 2018Review
- Rapamycin and CHIR99021 Coordinate Robust Cardiomyocyte Differentiation From Human Pluripotent Stem Cells Via Reducing p53-Dependent Apoptosis.Journal of the American Heart Association · 2017Article
- Wnt11 regulates cardiac chamber development and disease during perinatal maturation.JCI insight · 2017Article
- Tissue specific requirements for WNT11 in developing outflow tract and dorsal mesenchymal protrusion.Developmental biology · 2017Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Specification and early patterning of the vertebrate heart are dependent on both canonical and noncanonical wingless (Wnt) signal pathways. However, the impact of each Wnt pathway on the later stages of myocardial development and differentiation remains controversial. Here, we report that the components of each Wnt signal conduit are expressed in the developing and postnatal heart, yet canonical/β-catenin activity is restricted to nonmyocardial regions. Subsequently, we observed that noncanonical Wnt (Wnt11) enhanced myocyte differentiation while preventing stabilization of the β-catenin protein, suggesting active repression of canonical Wnt signals. Wnt11 stimulation was synonymous with activation of a caspase 3 signal cascade, while inhibition of caspase activity led to accumulation of β-catenin and a dramatic reduction in myocyte differentiation. Taken together, these results suggest that noncanonical Wnt signals promote myocyte maturation through caspase-mediated inhibition of β-catenin activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.