ArticleThe Journal of cell biology2010
Constitutive recycling of the store-operated Ca2+ channel Orai1 and its internalization during meiosis.
Article in The Journal of cell biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed.
- A Quartet of Native Orai Channel Isoforms Orchestrates Graded NFAT Activation and Transcription.bioRxiv : the preprint server for biology · 2026Article
- Identifying 2PHDO as a SOCE Inhibitor from Chinese Herbal Extracts.Current pharmaceutical biotechnology · 2026Article
- CaAdvances in experimental medicine and biology · 2023Article
- CRAC and SK Channels: Their Molecular Mechanisms Associated with Cancer Cell Development.Cancers · 2022Review
- Similarities and Differences between the Orai1 Variants: Orai1α and Orai1β.International journal of molecular sciences · 2022Review
- Article
- SPLUNC1 is a negative regulator of the Orai1 CaPhysiological reports · 2022Article
- CaJournal of immunology (Baltimore, Md. : 1950) · 2022Article
- The Role of Lipids in CRAC Channel Function.Biomolecules · 2022Review
- Highlighting the Multifaceted Role of Orai1 N-Terminal- and Loop Regions for Proper CRAC Channel Functions.Cells · 2022Review
- Orai1α, but not Orai1β, co-localizes with TRPC1 and is required for its plasma membrane location and activation in HeLa cells.Cellular and molecular life sciences : CMLS · 2022Article
- Orai1 Boosts SK3 Channel Activation.Cancers · 2021Article
- NKD2 mediates stimulation-dependent ORAI1 trafficking to augment CaCell reports · 2021Article
- The Orai1-AC8 Interplay: How Breast Cancer Cells Escape from Orai1 Channel Inactivation.Cells · 2021Review
- The N terminus of Orai1 couples to the AKAP79 signaling complex to drive NFAT1 activation by local CaProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Endoplasmic Reticulum-Plasma Membrane Contact Sites as an Organizing Principle for Compartmentalized Calcium and cAMP Signaling.International journal of molecular sciences · 2021Review
- Soluble αKlotho downregulates Orai1-mediated store-operated CaPflugers Archiv : European journal of physiology · 2021Article
- Caveolin-1 is Involved in Regulating the Biological Response of Cells to Nanosecond Pulsed Electric Fields.The Journal of membrane biology · 2021Article
- The carboxy terminal coiled-coil modulates Orai1 internalization during meiosis.Scientific reports · 2021Article
- Lysosomal agents inhibit store-operated CaJournal of cell science · 2021Article
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Authors and funding
3 authors.
Funding
Abstract
The egg's competency to activate at fertilization and transition to embryogenesis is dependent on its ability to generate a fertilization-specific Ca(2+) transient. To endow the egg with this capacity, Ca(2+) signals remodel during oocyte maturation, including inactivation of the primary Ca(2+) influx pathway store-operated Ca(2+) entry (SOCE). SOCE inactivation is coupled to internalization of the SOCE channel, Orai1. In this study, we show that Orai1 internalizes during meiosis through a caveolin (Cav)- and dynamin-dependent endocytic pathway. Cav binds to Orai1, and we map a Cav consensus-binding site in the Orai1 N terminus, which is required for Orai1 internalization. Furthermore, at rest, Orai1 actively recycles between an endosomal compartment and the cell membrane through a Rho-dependent endocytic pathway. A significant percentage of total Orai1 is intracellular at steady state. Store depletion completely shifts endosomal Orai1 to the cell membrane. These results define vesicular trafficking mechanisms in the oocyte that control Orai1 subcellular localization at steady state, during meiosis, and after store depletion.
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