ArticleThe Journal of biological chemistry2010
PDCD10/CCM3 acts downstream of {gamma}-protocadherins to regulate neuronal survival.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Structural insights into the in situ assembly of clustered protocadherin γB4.Nature communications · 2025Article
- Ubiquitination of the protocadherin-γA3 variable cytoplasmic domain modulates cell-cell interaction.Frontiers in cell and developmental biology · 2023Article
- Review
- The multifacetedGenes & diseases · 2021Review
- Expression of protocadherin-γC4 protein in the rat brain.The Journal of comparative neurology · 2020Article
- Protocadherins at the Crossroad of Signaling Pathways.Frontiers in molecular neuroscience · 2020Review
- Endothelial cell clonal expansion in the development of cerebral cavernous malformations.Nature communications · 2019Article
- How many cadherins do human endothelial cells express?Cellular and molecular life sciences : CMLS · 2019Review
- Biallelic CCM3 mutations cause a clonogenic survival advantage and endothelial cell stiffening.Journal of cellular and molecular medicine · 2019Article
- Multiple protocadherins are expressed in brain microvascular endothelial cells and might play a role in tight junction protein regulation.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
- Structural origins of clustered protocadherin-mediated neuronal barcoding.Seminars in cell & developmental biology · 2017Review
- The clustered protocadherin endolysosomal trafficking motif mediates cytoplasmic association.BMC cell biology · 2015Article
- Downregulation of programmed cell death 10 is associated with tumor cell proliferation, hyperangiogenesis and peritumoral edema in human glioblastoma.BMC cancer · 2015Article
- Article
- PTEN/PI3K/Akt/VEGF signaling and the cross talk to KRIT1, CCM2, and PDCD10 proteins in cerebral cavernous malformations.Neurosurgical review · 2015Review
- Ccm3, a gene associated with cerebral cavernous malformations, is required for neuronal migration.Development (Cambridge, England) · 2014Article
- Cerebral cavernous malformation proteins at a glance.Journal of cell science · 2014Review
- Functional DNA methylation differences between tissues, cell types, and across individuals discovered using the M&M algorithm.Genome research · 2013Article
- Article
- Molecular and functional interaction between protocadherin-γC5 and GABAA receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
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Authors and funding
4 authors.
Funding
Abstract
γ-Protocadherins (PCDH-γ) regulate neuronal survival in the vertebrate central nervous system. The molecular mechanisms of how PCDH-γ mediates this function are still not understood. In this study, we show that through their common cytoplasmic domain, different PCDH-γ isoforms interact with an intracellular adaptor protein named PDCD10 (programmed cell death 10). PDCD10 is also known as CCM3, a causative genetic defect for cerebral cavernous malformations in humans. Using RNAi-mediated knockdown, we demonstrate that PDCD10 is required for the occurrence of apoptosis upon PCDH-γ depletion in developing chicken spinal neurons. Moreover, overexpression of PDCD10 is sufficient to induce neuronal apoptosis. Taken together, our data reveal a novel function for PDCD10/CCM3, acting as a critical regulator of neuronal survival during development.
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