SynthesisThe American journal of psychiatry2010
Genome-wide association study of suicide attempts in mood disorder patients.
Synthesis in The American journal of psychiatry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 79 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
79 citing papers in PubMed, 3 syntheses or guidelines pooled it, 156 citations in OpenAlex.
- Genome-wide association study meta-analysis of suicide death and suicidal behavior.Molecular psychiatry · 2023Pooled it
- Genetics and epigenetics of self-injurious thoughts and behaviors: Systematic review of the suicide literature and methodological considerations.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2022Pooled it
- GWAS of Suicide Attempt in Psychiatric Disorders and Association With Major Depression Polygenic Risk Scores.The American journal of psychiatry · 2019Pooled it
- Suicide risk genes impact evolutionarily conserved survival strategies.Translational psychiatry · 2026Article
- Response and Adverse Effects to Lithium Treatment in Patients With Bipolar Disorder at Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia.BioMed research international · 2026Article
- Suicide risk genes impact evolutionarily conserved survival strategies.Research square · 2025Article
- Identification of Transdiagnostic Childhood Externalizing Pathology Within an Electronic Medical Records Database and Application to the Analysis of Rare Copy Number Variation.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2025Article
- Article
- Using the Strategy of Genome-Wide Association Studies to Identify Genetic Markers of Suicidal Behavior: A Narrative Review.Consortium psychiatricum · 2024Review
- Evolutionary conservation of putative suicidality-related risk genes that produce diminished motivation corrected by clozapine, lithium and antidepressants.Frontiers in psychiatry · 2024Article
- Temporal effects on death by suicide: empirical evidence and possible molecular correlates.Discover mental health · 2023Article
- Non-canonical pathways in the pathophysiology and therapeutics of bipolar disorder.Frontiers in neuroscience · 2023Review
- Passive and active suicidal ideation in a population-based sample of older adults: Associations with polygenic risk scores of relevance for suicidal behavior.Frontiers in psychiatry · 2023Article
- Suicide-Related Single Nucleotide Polymorphisms,Genes · 2022Article
- Saliva microbiome, dietary, and genetic markers are associated with suicidal ideation in university students.Scientific reports · 2022Article
- Genetic Association of Attention-Deficit/Hyperactivity Disorder and Major Depression With Suicidal Ideation and Attempts in Children: The Adolescent Brain Cognitive Development Study.Biological psychiatry · 2022Article
- Identification of potential blood biomarkers associated with suicide in major depressive disorder.Translational psychiatry · 2022Article
- Kidney cell type-specific changes in the chromatin and transcriptome landscapes following epithelialPhysiological genomics · 2022Article
- Association of Genome-Wide Polygenic Scores for Multiple Psychiatric and Common Traits in Preadolescent Youths at Risk of Suicide.JAMA network open · 2022Article
- ABI3BP is a prognosis biomarker related with clinicopathological features and immunity infiltration of lung tumor.Frontiers in genetics · 2022Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issuedSchulze, Thomas [corrected to Schulze, Thomas G]
Authors and funding
28 authors at 1 institution in 1 country.
Funding
Abstract
objectiveFamily and twin studies suggest that liability for suicide attempts is heritable and distinct from mood disorder susceptibility. The authors therefore examined the association between common genomewide variation and lifetime suicide attempts.
methodThe authors analyzed data on lifetime suicide attempts from genomewide association studies of bipolar I and II disorder as well as major depressive disorder. Bipolar disorder subjects were drawn from the Systematic Treatment Enhancement Program for Bipolar Disorder cohort, the Wellcome Trust Case Control Consortium bipolar cohort, and the University College London cohort. Replication was pursued in the NIMH Genetic Association Information Network bipolar disorder project and a German clinical cohort. Depression subjects were drawn from the Sequential Treatment Alternatives to Relieve Depression cohort, with replication in the Netherlands Study of Depression and Anxiety/Netherlands Twin Register depression cohort.
resultsStrongest evidence of association for suicide attempt in bipolar disorder was observed in a region without identified genes (rs1466846); five loci also showed suggestive evidence of association. In major depression, strongest evidence of association was observed for a single nucleotide polymorphism in ABI3BP, with six loci also showing suggestive association. Replication cohorts did not provide further support for these loci. However, meta-analysis incorporating approximately 8,700 mood disorder subjects identified four additional regions that met the threshold for suggestive association, including the locus containing the gene coding for protein kinase C-epsilon, previously implicated in models of mood and anxiety.
conclusionsThe results suggest that inherited risk for suicide among mood disorder patients is unlikely to be the result of individual common variants of large effect. They nonetheless provide suggestive evidence for multiple loci, which merit further investigation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.