ArticleJournal of ethnopharmacology2011
Identification and pharmacological characterization of the anti-inflammatory principal of the leaves of dwarf elder (Sambucus ebulus L.).
Article in Journal of ethnopharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 52 citations in OpenAlex.
- The effect of Sambucus nigra extract in the treatment of interstitial cystitis.The Canadian journal of urology · 2026Article
- Modulation of Endoplasmic Reticulum Stress by Selected Polyphenols fromPlants (Basel, Switzerland) · 2025Review
- Ethnopharmacological Survey of Plants Used as Folk Remedy in Gerze (Sinop, Türkiye).Turkish journal of pharmaceutical sciences · 2025Article
- Recent Advances in Phytochemical-Based Topical Applications for the Management of Eczema: A Review.International journal of molecular sciences · 2024Review
- In Vivo Anti-Inflammatory and Antinociceptive Activities of Black Elder (Pharmaceuticals (Basel, Switzerland) · 2024Article
- Ursolic acid enhances the effect of exercise training on vascular aging by reducing oxidative stress in aged type 2 diabetic rats.Food science & nutrition · 2023Article
- Phytochemical Composition, Anti-Inflammatory and ER Stress-Reducing Potential ofPlants (Basel, Switzerland) · 2021Article
- Inhibition of herpes simplex virus type 1 infection byMedical journal of the Islamic Republic of Iran · 2021Article
- The Inhibitory Effect of Plant Extracts on Growth of the Foodborne Pathogen,Antibiotics (Basel, Switzerland) · 2020Article
- Molecular cloning and in-depth bioinformatics analysis of type II ribosome-inactivating protein isolated fromSaudi journal of biological sciences · 2020Article
- Polyphenolic Extract fromNanomaterials (Basel, Switzerland) · 2019Article
- Potential anti-inflammatory, antioxidant and antimicrobial activities of Sambucus australis.Pharmaceutical biology · 2017Article
- Biological Effects and Clinical Applications of Dwarf Elder ( Sambucus ebulus L): A Review.Journal of evidence-based complementary & alternative medicine · 2017Review
- Turkish Scorzonera Species Extracts Attenuate Cytokine Secretion via Inhibition of NF-κB Activation, Showing Anti-Inflammatory Effect in Vitro.Molecules (Basel, Switzerland) · 2015Article
- Review
- Elderberries: a source of ribosome-inactivating proteins with lectin activity.Molecules (Basel, Switzerland) · 2015Review
- Effects of short-term heating on total polyphenols, anthocyanins, antioxidant activity and lectins of different parts of dwarf elder (Sambucus ebulus L.).Plant foods for human nutrition (Dordrecht, Netherlands) · 2014Article
- Article
- Ethnopharmacological in vitro studies on Austria's folk medicine--an unexplored lore in vitro anti-inflammatory activities of 71 Austrian traditional herbal drugs.Journal of ethnopharmacology · 2013Article
- Inhibition of cell surface expression of endothelial adhesion molecules by ursolic acid prevents intimal hyperplasia of venous bypass grafts in rats.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2012Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aim of the studyThe performed investigations aimed on the identification of the anti-inflammatory principal of extracts of leaves of Sambucus ebulus L. (dwarf elder) in order to rationalize the traditional use of this plant for the treatment of chronically inflammatory diseases. MATERIALS AND
methodsDwarf elder leaf extract was subjected to activity guided fractionation using inhibition of TNFα induced expression of vascular cell adhesion molecule 1 (VCAM-1) on the surface of human umbilical vein endothelial cells (HUVECs) as monitoring tool (positive control: parthenolide 10μM, VCAM-1 expression (% of control): 5.35±0.38%).
resultsBio-guided isolation resulted in identification of ursolic acid as anti-inflammatory principal. Besides its inhibitory effects against TNFα induced expression of VCAM-1 (IC(50) 6.25 μM), ursolic acid inhibits also TNFα induced expression of ICAM-1 (IC(50) value between 3.13 and 6.25 μM) (positive control: parthenolide 10 μM, ICAM-1 expression (% of control): 38.89±16.6%). Toxic effects of ursolic acid on HUVECs can be drastically reduced using an enriched extract instead of the pure compound.
conclusionsOur findings suggest an additional mechanism of the anti-inflammatory activity of ursolic acid by demonstrating its ability to inhibit TNFα-stimulated expression of VCAM-1 and ICAM-1 and support the traditional use of extracts and preparations of Sambucus ebulus L., rich in ursolic acid, for the treatment of chronically inflammatory processes.
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