Evidence map›Paper›PMID 21040721›Full record

ReviewExperimental cell research2011

Chemokines as mediators of tumor angiogenesis and neovascularization.

Ellen C Keeley, Borna Mehrad, Robert M Strieter

Abstract readReview
In one paragraph

Review in Experimental cell research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 122 citations in OpenAlex.

  1. CXCR4, CXCL12 and the relative CXCL12-CXCR4 expression as prognostic factors in colon cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016
    Trial
  2. Murine Cell Line Models for Vascular Mimicry: The Role of YAP/TAZ Signaling.International journal of molecular sciences · 2025
    Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Systemic and vitreous biomarkers - new insights in diabetic retinopathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022
    Observational
  10. Article
  11. Review
  12. Article
  13. Observational
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ellen C KeeleyDepartment of Medicine, Division of Cardiology, University of Virginia, Charlottesville, VA, USA.
Borna Mehrad
Robert M Strieter
University of Virginia · US

Funding

UVA Digestive Health Research CenterP30DK067629 · NIDDK · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI COHN, STEVEN M · 2004 to 2008
$5.6M
CXC Chemokines in CancerR01CA087879 · NCI · UNIVERSITY OF VIRGINIA · PI STRIETER, ROBERT M · 2000 to 2010
$3.4M
NK cells in host defense against invasive aspergillosisR01HL073848 · NHLBI · UNIVERSITY OF VIRGINIA · PI MEHRAD, BORNA · 2003 to 2013
$3.3M
Chemokines and Fibrocytes in Acute Lung InjuryR01HL066027 · NHLBI · UNIVERSITY OF VIRGINIA · PI STRIETER, ROBERT M · 2001 to 2009
$3.2M
Fibrocytes in the Pathogenesis of Sickle Cell Lung DiseaseR01HL098526 · NHLBI · UNIVERSITY OF VIRGINIA · PI ROSE, C EDWARD · 2010 to 2013
$2.0M
Chemokines and Neovascularization in Coronary Artery DiseaseK23HL097074 · NHLBI · UNIVERSITY OF VIRGINIA · PI KEELEY, ELLEN CATHERINE · 2009 to 2013
$676k
NCI NIH HHS CA87879NCI NIH HHS R01 CA087879NHLBI NIH HHS HL66027NHLBI NIH HHS HL73848NHLBI NIH HHS HL97074NHLBI NIH HHS HL98526NHLBI NIH HHS K23 HL097074NHLBI NIH HHS R01 HL066027NHLBI NIH HHS R01 HL073848NHLBI NIH HHS R01 HL098526NIDDK NIH HHS P30 DK067629
6 · The paper itself

Abstract

Chemokines are a superfamily of structurally homologous heparin-binding proteins that influence tumor growth and metastasis. Several members of the CXC and CC chemokine families are potent inducers of neovascularization, whereas a subset of the CXC chemokines are potent inhibitors. In this paper, we review the current literature regarding the role of chemokines as mediators of tumor angiogenesis and neovascularization.

Indexed as

Neovascularization, PathologicAnimalsChemokinesHumansNeoplasmsChemokines

Identifiers

PMID21040721
PMCPMC3073599
OpenAlexW1972794546

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.