ReviewExpert reviews in molecular medicine2010
Novel insights into molecular mechanisms of abruption-induced preterm birth.
Review in Expert reviews in molecular medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Molecular Changes on Maternal-Fetal Interface in Placental Abruption-A Systematic Review.International journal of molecular sciences · 2021Pooled it
- Multiple Placental Abruptions With Fetal Loss: A Case Report and Review of the Literature.Cureus · 2025Article
- Association of maternal calprotectin plasma levels with abruption placenta.BMC pregnancy and childbirth · 2025Article
- Predictors of Inflammation-Mediated Preterm Birth.Physiology (Bethesda, Md.) · 2025Review
- Review
- Challenges in Using Progestin to Prevent Singleton Preterm Births: Current Knowledge and Clinical Advice.International journal of women's health · 2024Review
- Decreased level of TREM like Transcript 1 (TLT-1) is associated with prematurity and promotes the in-utero inflammatory response to maternal lipopolysaccharide (LPS) exposure.American journal of reproductive immunology (New York, N.Y. : 1989) · 2023Article
- Bloody Amniotic Fluid and Neonatal Outcomes.Children (Basel, Switzerland) · 2023Article
- Placental abruption at near-term and term gestations: pathophysiology, epidemiology, diagnosis, and management.American journal of obstetrics and gynecology · 2023Review
- Pyoderma gangrenosum following an unplanned caesarean section: a patient revisited.BMJ case reports · 2021Article
- Thrombin Alters Human Endometrial Stromal Cell Differentiation During Decidualization.Reproductive sciences (Thousand Oaks, Calif.) · 2019Article
- Thrombin Augments LPS-Induced Human Endometrial Endothelial Cell Inflammation via PAR1 Activation.American journal of reproductive immunology (New York, N.Y. : 1989) · 2016Article
- Advances in medical diagnosis of intra-amniotic infection.Expert opinion on medical diagnostics · 2013Review
- Phospholipid scramblase expression in the pregnant mouse uterus in LPS-induced preterm delivery.Reproductive sciences (Thousand Oaks, Calif.) · 2012Article
- Tissue factor-dependent thrombin generation across pregnancy.American journal of obstetrics and gynecology · 2012Article
- Proteomics/diagnosis of chorioamnionitis and of relationships with the fetal exposome.Seminars in fetal & neonatal medicine · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Preterm birth (PTB) complicates more than 12% of all deliveries. Despite significant research, the aetiology of most cases of PTB remains elusive. Two major antecedents of PTB, intra-amniotic infection and decidual haemorrhage (abruption), can exhibit dissimilar demographic and genetic predispositions, despite sharing common molecular and cellular pathways. The use of high-throughput, high-dimensional technologies reveals substantial crosstalk between the coagulation and inflammation pathways. Tissue factor, thrombin and cytokines are key mediators of this crosstalk. Abruptions are associated with excess thrombin generated from decidual-cell-expressed tissue factor. Although thrombin is a primary mediator of the coagulation cascade, it can also promote inflammation-associated PTB by enhancing expression of matrix metalloproteinase and neutrophil-chemoattracting and -activating chemokines. Here, we provide novel insights into the molecular mechanisms and pathways leading to PTB in the setting of placental abruption.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.