ReviewJournal of neuroinflammation2010
The dual role of the neuroinflammatory response after ischemic stroke: modulatory effects of hypothermia.
Review in Journal of neuroinflammation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 176 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
176 citing papers in PubMed, 349 citations in OpenAlex.
- Unveiling the "Glycolysis-Lactate-Lactylation" Axis: A Novel Target in Ischemic Cerebrovascular Disease.Neuroscience bulletin · 2026Review
- Aldose reductase inhibition suppresses microglial endoplasmic reticulum stress and ferritinophagy in ischemic stroke.Acta pharmacologica Sinica · 2026Article
- Potential of Saliva in Stroke Patients: A Review.International journal of molecular sciences · 2026Review
- Serum Neurofilament Light Chain Predicts Stroke Outcome and is a Potential Marker for Treatment Effects of Neural Stem Cell-derived Extracellular Vesicles in a Rat Stroke Model.Translational stroke research · 2026Article
- Neuroinflammation strokes the brain: A double-edged sword in ischemic stroke.Neural regeneration research · 2026Article
- Association of the Naples Prognostic Score With Functional Outcomes and the Mediating Effects of PhenoAge Acceleration in Patients With Acute Ischemic Stroke or Transient Ischemic Attack: A Nationwide Registry Study.Journal of the American Heart Association · 2026Article
- Predictive value of gut metabolites combined with neutrophil to platelet ratio for clinical functional outcome in acute ischemic stroke treated with endovascular therapy.Frontiers in nutrition · 2026Article
- Relationship of S100 Proteins with Neuroinflammation.Biomolecules · 2025Review
- Correlation Between NLR to Albumin Ratio and 90-day Prognosis After Treatment for Acute Ischemic Stroke.Journal of cardiovascular translational research · 2025Article
- Neuroinflammation: Mechanisms, Dual Roles, and Therapeutic Strategies in Neurological Disorders.Current issues in molecular biology · 2025Review
- Lactylation and Ischemic Stroke: Research Progress and Potential Relationship.Molecular neurobiology · 2025Review
- Association of immunonutritional indicators with all-cause mortality in adult stroke patients.Scientific reports · 2025Article
- Risk Warning of Neutrophil-to-Lymphocyte Ratio for Neurological Recovery in Acute Ischemic Stroke After Thrombolysis: A Retrospective Study.Brain and behavior · 2025Article
- Structural and functional brain correlates of the neutrophil- and monocyte-to-lymphocyte ratio in neuropsychiatric disorders.Brain, behavior, & immunity - health · 2025Article
- Nomogram model for decompressing craniectomy after mechanical thrombectomy in patients with acute ischemic stroke.Scientific reports · 2025Article
- The mediation of systemic inflammation on insulin resistance and poor prognosis in non-diabetic ischemic stroke patients treated with intravenous thrombolysis.Frontiers in neurology · 2025Article
- High-Mobility Group Box-1 as a Predictor for Malignant Brain Edema Following Mechanical Thrombectomy in Acute Ischemic Stroke Patients.International journal of general medicine · 2025Article
- Hidden risk patterns among acute ischemic stroke patients identified by latent class analysis.Frontiers in neurology · 2025Article
- Uncovering a new mechanism of ischemic stroke: a study of the association between γδ T cells and immunoinflammation.Frontiers in immunology · 2025Review
- Association of neutrophil-to-lymphocyte ratio with stroke morbidity and mortality: evidence from the NHANES 1999-2020.Frontiers in medicine · 2025Article
116 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuroinflammation is a key element in the ischemic cascade after cerebral ischemia that results in cell damage and death in the subacute phase. However, anti-inflammatory drugs do not improve outcome in clinical settings suggesting that the neuroinflammatory response after an ischemic stroke is not entirely detrimental. This review describes the different key players in neuroinflammation and their possible detrimental and protective effects in stroke. Because of its inhibitory influence on several pathways of the ischemic cascade, hypothermia has been introduced as a promising neuroprotective strategy. This review also discusses the influence of hypothermia on the neuroinflammatory response. We conclude that hypothermia exerts both stimulating and inhibiting effects on different aspects of neuroinflammation and hypothesize that these effects are key to neuroprotection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.