Evidence map›Paper›PMID 21040443›Full record

SynthesisJournal of thrombosis and haemostasis : JTH2011

Risk factors for catheter-related thrombosis (CRT) in cancer patients: a patient-level data (IPD) meta-analysis of clinical trials and prospective studies.

W Saber, T Moua, E C Williams, M Verso, G Agnelli, S Couban, A Young, M De Cicco, R Biffi, C J van Rooden and 8 more

Registry-linked trialOpen access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of thrombosis and haemostasis : JTH, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02025894 (Risk Factors for Thromboembolic and Infectious Complications Related to Percutaneous Central Venous Catheters in Cancer - Prospective Multicenter Study), which is not on this map. Cited by 91 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed, 11 pooled it
16.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02025894 completednot on this map

Risk Factors for Thromboembolic and Infectious Complications Related to Percutaneous Central Venous Catheters in Cancer - Prospective Multicenter Study

TypeobservationalSponsorInstitut de Cancérologie de la LoireRan2010 to 2015Enrolled3,032ConditionsCancer
3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 11 syntheses or guidelines pooled it, 234 citations in OpenAlex.

  1. Pooled it
  2. SEOM clinical guidelines on venous thromboembolism (VTE) and cancer (2023).Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
    Guideline
  3. Pooled it
  4. Pooled it
  5. SEOM clinical guideline of venous thromboembolism (VTE) and cancer (2019).Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2020
    Guideline
  6. Pooled it
  7. Pooled it
  8. Clinical guide SEOM on venous thromboembolism in cancer patients.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2014
    Guideline
  9. Pooled it
  10. Pooled it
  11. Guideline
  12. Trial
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Sex Differences in Cancer-Associated Thrombosis.International journal of molecular sciences · 2026
    Review

31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 13 institutions in 5 countries.

W SaberUniversity of Wisconsin School of Medicine and Public Health, Madison, WI, USA. wsaber@mcw.edu
T Moua
E C Williams
M Verso
G Agnelli
S Couban
A Young
M De Cicco
R Biffi
C J van Rooden
M V Huisman
D Fagnani
C Cimminiello
M Moia
M Magagnoli
S P Povoski
S F Malak
A Y Lee
University of Wisconsin–Madison · USAzienda Ospedaliera di Desio e Vimercate · ITLeiden University · NLUniversity of Perugia · ITCentro di Riferimento Oncologico · ITEuropean Institute of Oncology · ITFondazione Humanitas per la Ricerca · ITQueen Elizabeth II Health Sciences Centre · CAThe Ohio State University · USUniversity of Arkansas for Medical Sciences · USUniversity of Birmingham · GBUniversity of British Columbia · CAUniversity of Milan · IT

Funding

RESEARCH TRAINING IN HEMATOLOGYT32HL007899 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Jane Ellen Churpek · 1998 to 2026
$8.2M
NHLBI NIH HHS T32 HL007899NHLBI NIH HHS T32 HL07899-09
6 · The paper itself

Abstract

backgroundKnowledge of independent, baseline risk factors for catheter-related thrombosis (CRT) may help select adult cancer patients who are at high risk to receive thromboprophylaxis.

objectivesWe conducted a meta-analysis of individual patient-level data to identify these baseline risk factors. PATIENTS/

methodsMEDLINE, EMBASE, CINAHL, CENTRAL, DARE and the Grey literature databases were searched in all languages from 1995 to 2008. Prospective studies and randomized controlled trials (RCTs) were eligible. Studies were included if original patient-level data were provided by the investigators and if CRT was objectively confirmed with valid imaging. Multivariate logistic regression analysis of 17 prespecified baseline characteristics was conducted. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated.

resultsA total sample of 5636 subjects from five RCTs and seven prospective studies was included in the analysis. Among these subjects, 425 CRT events were observed. In multivariate logistic regression, the use of implanted ports as compared with peripherally implanted central venous catheters (PICCs), decreased CRT risk (OR, 0.43; 95% CI, 0.23-0.80), whereas past history of deep vein thrombosis (DVT) (OR, 2.03; 95% CI, 1.05-3.92), subclavian venipuncture insertion technique (OR, 2.16; 95% CI, 1.07-4.34) and improper catheter tip location (OR, 1.92; 95% CI, 1.22-3.02), increased CRT risk.

conclusionsCRT risk is increased with use of PICCs, previous history of DVT, subclavian venipuncture insertion technique and improper positioning of the catheter tip. These factors may be useful for risk stratifying patients to select those for thromboprophylaxis. Prospective studies are needed to validate these findings.

Indexed as

Clinical Trials as TopicCatheterization, Central VenousHumansNeoplasmsProspective StudiesRisk FactorsThrombosis

Identifiers

PMID21040443
PMCPMC4282796
OpenAlexW2100994130

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.