ArticleThe European journal of neuroscience2010
Lack of protein-tyrosine sulfation disrupts photoreceptor outer segment morphogenesis, retinal function and retinal anatomy.
Article in The European journal of neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- Proteome-Wide Association Study for Finding Druggable Targets in Progression and Onset of Parkinson's Disease.CNS neuroscience & therapeutics · 2025Article
- Causal relationships of familial hypercholesterolemia with the risk of multiple vitamin deficiencies: a Mendelian randomization study.Frontiers in endocrinology · 2024Article
- Engineering of SH2 Domains for the Recognition of Protein Tyrosine O-Sulfation Sites.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Sulfotransferase activity contributes to long-term potentiation and long-term memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2022Article
- Engineering of a Small Protein Scaffold To Recognize Sulfotyrosine with High Specificity.ACS chemical biology · 2021Article
- Silicon Nanowire Field-Effect Transistor as Biosensing Platforms for Post-Translational Modification.Biosensors · 2020Article
- Bright flash response recovery of mammalian rods in vivo is rate limited by RGS9.The Journal of general physiology · 2017Article
- Glycosylation of rhodopsin is necessary for its stability and incorporation into photoreceptor outer segment discs.Human molecular genetics · 2015Article
- Role of tyrosine-sulfated proteins in retinal structure and function.Experimental eye research · 2015Review
- Tyrosine sulfation as a protein post-translational modification.Molecules (Basel, Switzerland) · 2015Review
- Fibulin 2, a tyrosine O-sulfated protein, is up-regulated following retinal detachment.The Journal of biological chemistry · 2014Article
- Complement factor H, vitronectin, and opticin are tyrosine-sulfated proteins of the retinal pigment epithelium.PloS one · 2014Article
- A perspective on the role of the extracellular matrix in progressive retinal degenerative disorders.Investigative ophthalmology & visual science · 2013Review
- P-Rex2, a Rac-guanine nucleotide exchange factor, is expressed selectively in ribbon synaptic terminals of the mouse retina.BMC neuroscience · 2013Article
- Article
- Focus on molecules: sulfotyrosine.Experimental eye research · 2012Article
- Pattern of expression of p53, its family members, and regulators during early ocular development and in the post-mitotic retina.Investigative ophthalmology & visual science · 2012Article
- CNGA3 deficiency affects cone synaptic terminal structure and function and leads to secondary rod dysfunction and degeneration.Investigative ophthalmology & visual science · 2012Article
- Differential developmental deficits in retinal function in the absence of either protein tyrosine sulfotransferase-1 or -2.PloS one · 2012Article
- Early-onset, slow progression of cone photoreceptor dysfunction and degeneration in CNG channel subunit CNGB3 deficiency.Investigative ophthalmology & visual science · 2011Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
To investigate the role(s) of protein-tyrosine sulfation in the retina, we examined retinal function and structure in mice lacking tyrosylprotein sulfotransferases (TPST) 1 and 2. Tpst double knockout (DKO; Tpst1(-/-) /Tpst2 (-/-) ) retinas had drastically reduced electroretinographic responses, although their photoreceptors exhibited normal responses in single cell recordings. These retinas appeared normal histologically; however, the rod photoreceptors had ultrastructurally abnormal outer segments, with membrane evulsions into the extracellular space, irregular disc membrane spacing and expanded intradiscal space. Photoreceptor synaptic terminals were disorganized in Tpst DKO retinas, but established ultrastructurally normal synapses, as did bipolar and amacrine cells; however, the morphology and organization of neuronal processes in the inner retina were abnormal. These results indicate that protein-tyrosine sulfation is essential for proper outer segment morphogenesis and synaptic function, but is not critical for overall retinal structure or synapse formation, and may serve broader functions in neuronal development and maintenance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.