ArticleAlcoholism, clinical and experimental research2011
Increased ethanol consumption and preference in mice lacking neurotensin receptor type 2.
Article in Alcoholism, clinical and experimental research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
- Mouse parasubthalamicbioRxiv : the preprint server for biology · 2024Article
- GABA release from central amygdala neurotensin neurons differentially modulates ethanol consumption in male and female mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Neurotensin and Neurotensin Receptors in Stress-related Disorders: Pathophysiology & Novel Drug Targets.Current neuropharmacology · 2024Review
- GABA Release From Central Amygdala Neurotensin Neurons Differentially Modulates Reward and Consummatory Behavior in Male and Female Mice.bioRxiv : the preprint server for biology · 2023Article
- Neurotensin and Alcohol Use Disorders: Towards a Pharmacological Treatment.International journal of molecular sciences · 2023Review
- Therapeutic strategies of small molecules in the microbiota-gut-brain axis for alcohol use disorder.Drug discovery today · 2023Review
- Actions of feeding-related peptides on the mesolimbic dopamine system in regulation of natural and drug rewards.Addiction neuroscience · 2022Article
- Circuit and neuropeptide mechanisms of the paraventricular thalamus across stages of alcohol and drug use.Neuropharmacology · 2021Review
- Heightened Exploratory Behavior Following Chronic Excessive Ethanol Drinking: Mediation by Neurotensin Receptor Type 2 in the Anterior Paraventricular Thalamus.Alcoholism, clinical and experimental research · 2020Article
- Manipulations of Central Amygdala Neurotensin Neurons Alter the Consumption of Ethanol and Sweet Fluids in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Behavioral and Neurobiological Consequences of Hedonic Feeding on Alcohol Drinking.Current pharmaceutical design · 2020Review
- Chronic caffeine exposure in adolescence promotes diurnal, biphasic mood-cycling and enhanced motivation for reward in adult mice.Behavioural brain research · 2019Article
- Oxytocin pathway gene networks in the human brain.Nature communications · 2019Article
- Neurotensin in the posterior thalamic paraventricular nucleus: inhibitor of pharmacologically relevant ethanol drinking.Addiction biology · 2019Article
- Genes and Alcohol Consumption: Studies with Mutant Mice.International review of neurobiology · 2016Review
- To ingest or rest? Specialized roles of lateral hypothalamic area neurons in coordinating energy balance.Frontiers in systems neuroscience · 2015Review
- Elucidating the role of neurotensin in the pathophysiology and management of major mental disorders.Behavioral sciences (Basel, Switzerland) · 2014Review
- Gut-brain peptides in corticostriatal-limbic circuitry and alcohol use disorders.Frontiers in neuroscience · 2014Review
- Article
- Selection for drinking in the dark alters brain gene coexpression networks.Alcoholism, clinical and experimental research · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundNeurotensin receptors (NTS) regulate a variety of the biological functions of neurotensin (NT) in the central nervous system. Although NT and neurotensin receptors type 1 (NTS1) are implicated in some of the behavioral effects of ethanol, the functional roles of neurotensin receptors type 2 (NTS2) in ethanol intoxication and consumption remain unknown. Here, we investigated behavioral effects mediated by NTS2 in response to ethanol, which are implicated in ethanol consumption and preference, using NTS2 null mice.
methodFirst, we examined ethanol-induced locomotion, ataxia, hypnosis, and hypothermia in NTS2 null mice. Next, we measured ethanol consumption and preference in NTS2 null mice by giving them free choice between ethanol- and tap water-containing bottles. Then using a brain-permeable NT analog, NT69L, we examined the role of NTS2 in locomotor activity and ataxia. Finally, we examined the effect of NT69L on ethanol consumption and preference in NTS2 null mice.
resultsWe found that NTS2 null mice appear less sensitive to the acute hypnotic effects of ethanol and consumed more ethanol compared to wild-type littermates in a 2-bottle choice experiment, even though ethanol-induced locomotion, ataxia, and hypothermia were similar between genotypes. Interestingly, the administration of NT69L for 4 consecutive days significantly reduced alcohol consumption and preference in wild-type littermates as well as in NTS2 null mice.
conclusionsOur findings suggest that NTS2 regulates ethanol-induced hypnosis and ethanol consumption.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.