ArticleDevelopmental psychology2011
Prenatal tobacco exposure: developmental outcomes in the neonatal period.
Article in Developmental psychology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
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Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Vaping and Smoking in Pregnancy-A Meta-Analysis of Neurobehavioural Development in Prenatally Exposed Offspring.Acta paediatrica (Oslo, Norway : 1992) · 2025Pooled it
- Infant neurobehavioural consequences of prenatal cigarette exposure: A systematic review and meta-analysis.Acta paediatrica (Oslo, Norway : 1992) · 2020Pooled it
- Impact of Maternal Smoking During Pregnancy on Fetal and Neonatal Neurobehavioral Development: A Narrative Review.Rhode Island medical journal (2013) · 2026Review
- Secondhand smoke exposure during pregnancy: Nicotine metabolites in maternal urine and breast milk as biomarkers of infant birth weight and length, a cross-sectional study.Tobacco induced diseases · 2026Article
- Perinatal nicotine-induced neurotoxicity and behavioral alterations in newborn mice are associated with oxidative stress, inflammation and downregulated Nrf2/HO-1 signaling: protective role of Anethum graveolens.Journal of molecular histology · 2025Article
- Prenatal Tobacco Exposure and Behavioral Disorders in Children and Adolescents: Systematic Review and Meta-Analysis.Pediatric reports · 2024Review
- Prenatal tobacco and alcohol exposure, white matter microstructure, and early language skills in toddlers from a South African birth cohort.Frontiers in integrative neuroscience · 2024Article
- Exploring the interplay of dopaminergic genotype and parental behavior in relation to executive function in early childhood.Development and psychopathology · 2023Article
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- Prenatal substance exposure and maternal hostility from pregnancy to toddlerhood: Associations with temperament profiles at 16 months of age.Development and psychopathology · 2021Article
- Psychopathology Symptoms are Associated with Prenatal Health Practices in Pregnant Women with Heavy Smoking Levels.Maternal and child health journal · 2021Article
- Selective Expression of Nicotinic Receptor Sub-unit mRNA in Early Human Fetal Forebrain.Frontiers in molecular neuroscience · 2020Article
- Placental microRNAs: Responders to environmental chemicals and mediators of pathophysiology of the human placenta.Toxicology reports · 2020Review
- Does early maternal responsiveness buffer prenatal tobacco exposure effects on young children's behavioral disinhibition?Development and psychopathology · 2019Article
- Age of initiation of cigarette smoking and smokeless tobacco use among western Alaska Native people: Secondary analysis of the WATCH study.Addictive behaviors reports · 2019Article
- The cellular basis of fetal endoplasmic reticulum stress and oxidative stress in drug-induced neurodevelopmental deficits.Neurobiology of stress · 2019Review
- Maternal smoking during pregnancy and offspring executive function: What do we know and what are the next steps?Development and psychopathology · 2018Review
- Impact of maternal prenatal smoking on fetal to infant neurobehavioral development.Development and psychopathology · 2018Article
- Developmental nicotine exposure affects larval brain size and the adult dopaminergic system of Drosophila melanogaster.BMC developmental biology · 2018Article
- Article
Corrections and comments
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5 authors.
Funding
Abstract
Smoking during pregnancy is a persistent public health problem that has been linked to later adverse outcomes. The neonatal period--the first month of life--carries substantial developmental change in regulatory skills and is the period when tobacco metabolites are cleared physiologically. Studies to date mostly have used cross-sectional designs that limit characterizing potential impacts of prenatal tobacco exposure on the development of key self-regulatory processes and cannot disentangle short-term withdrawal effects from residual exposure-related impacts. In this study, pregnant participants (N = 304) were recruited prospectively during pregnancy, and smoking was measured at multiple time points, with both self-report and biochemical measures. Neonatal attention, irritable reactivity, and stress dysregulation were examined longitudinally at three time points during the first month of life, and physical growth indices were measured at birth. Tobacco-exposed infants showed significantly poorer attention skills after birth, and the magnitude of the difference between exposed and nonexposed groups attenuated across the neonatal period. In contrast, exposure-related differences in irritable reactivity largely were not evident across the 1st month of life, differing marginally at 4 weeks of age only. Third-trimester smoking was associated with pervasive, deleterious, dose–response impacts on physical growth measured at birth, whereas nearly all smoking indicators throughout pregnancy predicted level and growth rates of early attention. The observed neonatal pattern is consistent with the neurobiology of tobacco on the developing nervous system and fits with developmental vulnerabilities observed later in life.
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