ArticleJournal of the American Chemical Society2010
Discrete structure of an RNA folding intermediate revealed by cryo-electron microscopy.
Article in Journal of the American Chemical Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Tertiary folds of the SL5 RNA from the 5' proximal region of SARS-CoV-2 and related coronaviruses.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Tertiary folds of the SL5 RNA from the 5' proximal region of SARS-CoV-2 and related coronaviruses.bioRxiv : the preprint server for biology · 2023Article
- A viral RNA hijacks host machinery using dynamic conformational changes of a tRNA-like structure.Science (New York, N.Y.) · 2021Article
- Hierarchical natural move Monte Carlo refines flexible RNA structures into cryo-EM densities.RNA (New York, N.Y.) · 2020Article
- Advances that facilitate the study of large RNA structure and dynamics by nuclear magnetic resonance spectroscopy.Wiley interdisciplinary reviews. RNA · 2019Review
- What is the best reference state for building statistical potentials in RNA 3D structure evaluation?RNA (New York, N.Y.) · 2019Article
- Structure of the 30 kDa HIV-1 RNA Dimerization Signal by a Hybrid Cryo-EM, NMR, and Molecular Dynamics Approach.Structure (London, England : 1993) · 2018Article
- Nanopore electric snapshots of an RNA tertiary folding pathway.Nature communications · 2017Article
- RNA folding pathways and kinetics using 2D energy landscapes.Journal of mathematical biology · 2015Article
- Conjoined use of EM and NMR in RNA structure refinement.PloS one · 2015Article
- Structural dynamics of a mitochondrial tRNA possessing weak thermodynamic stability.Biochemistry · 2014Article
- Visualizing large RNA molecules in solution.RNA (New York, N.Y.) · 2012Article
- Site-specific platinum(II) cross-linking in a ribozyme active site.Journal of the American Chemical Society · 2012Article
- Ensemble of secondary structures for encapsidated satellite tobacco mosaic virus RNA consistent with chemical probing and crystallography constraints.Biophysical journal · 2011Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
RNA folding occurs via a series of transitions between metastable intermediate states. It is unknown whether folding intermediates are discrete structures folding along defined pathways or heterogeneous ensembles folding along broad landscapes. We use cryo-electron microscopy and single-particle image reconstruction to determine the structure of the major folding intermediate of the specificity domain of a ribonuclease P ribozyme. Our results support the existence of a discrete conformation for this folding intermediate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.