ArticleJournal of immunology (Baltimore, Md. : 1950)2010
IL-2 complex treatment can protect naive mice from bacterial and viral infection.
Article in Journal of immunology (Baltimore, Md. : 1950), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- A hypomorphic Il2rb mutant mouse model recapitulates and reveals mechanisms of human T cell immune dysregulation in IL-2Rβ deficiency.Cell reports · 2025Article
- The Predictive Significance of Interleukin-2 Receptor in Patients with Hepatocellular Carcinoma.Journal of hepatocellular carcinoma · 2025Article
- Immune Signatures Distinguish Pure and Mixed Sepsis in Critical COVID-19: A Retrospective Cohort Study.Journal of inflammation research · 2025Article
- Treatment of mice with S4B6 IL-2 complex prevents lethal toxoplasmosis via IL-12- and IL-18-dependent interferon-gamma production by non-CD4 immune cells.Scientific reports · 2020Article
- Contributions of natural killer cells to the immune response against Plasmodium.Malaria journal · 2019Review
- Antitumor Effects and Related Mechanisms of Ethyl Acetate Extracts ofFrontiers in oncology · 2019Article
- Polymicrobial sepsis influences NK-cell-mediated immunity by diminishing NK-cell-intrinsic receptor-mediated effector responses to viral ligands or infections.PLoS pathogens · 2018Article
- Interleukin-15 Complex Treatment Protects Mice from Cerebral Malaria by Inducing Interleukin-10-Producing Natural Killer Cells.Immunity · 2018Article
- IL-2 and Beyond in Cancer Immunotherapy.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2018Review
- Cutting Edge: The Aging Immune System Reveals the Biological Impact of Direct Antigen Presentation on CD8 T Cell Responses.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- IL-2 complex treatment amplifies CD8Microbes and infection · 2016Article
- Normalizing the environment recapitulates adult human immune traits in laboratory mice.Nature · 2016Article
- IL-2/anti-IL-2 mAb immunocomplexes: A renascence of IL-2 in cancer immunotherapy?Oncoimmunology · 2016Review
- A Generic Mechanism for Enhanced Cytokine Signaling via Cytokine-Neutralizing Antibodies.PloS one · 2016Article
- A Mouse Model of Latent Tuberculosis Infection to Study Intervention Strategies to Prevent Reactivation.PloS one · 2016Article
- An Excess of the Proinflammatory Cytokines IFN-γ and IL-12 Impairs the Development of the Memory CD8+ T Cell Response to Chlamydia trachomatis.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Activated regulatory T cells suppress effector NK cell responses by an IL-2-mediated mechanism during an acute retroviral infection.Retrovirology · 2015Article
- Ikaros imposes a barrier to CD8+ T cell differentiation by restricting autocrine IL-2 production.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Article
- Challenges and developing solutions for increasing the benefits of IL-2 treatment in tumor therapy.Expert review of clinical immunology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
IL-2 complexes have substantial effects on the cellular immune system, and this approach is being explored for therapeutic application in infection and cancer. However, the impact of such treatments on subsequent encounter with pathogens has not been investigated. In this study, we report that naive mice treated with a short course of IL-2 complexes show enhanced protection from newly encountered bacterial and viral infections. IL-2 complex treatment expands both the NK and CD8 memory cell pool, including a recently described population of preexisting memory-phenotype T cells responsive to previously unencountered foreign Ags. Surprisingly, prolonged IL-2 complex treatment decreased CD8 T cell function and protective immunity. These data reveal the impact of cytokine complex treatment on the primary response to infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.