ArticleJournal of immunology (Baltimore, Md. : 1950)2010
Cutting edge: adaptive versus innate receptor signals selectively control the pool sizes of murine IFN-γ- or IL-17-producing γδ T cells upon infection.
Article in Journal of immunology (Baltimore, Md. : 1950), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
53 citing papers in PubMed, 101 citations in OpenAlex.
- Human lung γδ T cells maintain functionality during inflammatory lung disease.bioRxiv : the preprint server for biology · 2026Article
- Signature cytokine-associated transcriptome analysis of effector γδ T cells identifies subset-specific regulators of peripheral activation.Nature immunology · 2025Article
- Selective regulation of IFN-γ and IL-4 co-producing unconventional T cells by purinergic signaling.The Journal of experimental medicine · 2024Article
- IL-27 maintains cytotoxic Ly6CThe EMBO journal · 2024Article
- γδ T Cells Mediate a Requisite Portion of a Wound Healing Response Triggered by Cutaneous Poxvirus Infection.Viruses · 2024Article
- Cytokines, synaptic plasticity and network dynamics: a matter of balance.Neural regeneration research · 2023Review
- IL-17a-producing γδT cells and NKG2D signaling mediate bacterial endotoxin-induced neonatal lung injury: implications for bronchopulmonary dysplasia.Frontiers in immunology · 2023Article
- γδ T Cells Activated in Different Inflammatory Environments Are Functionally Distinct.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Cancer cell-expressed BTNL2 facilitates tumour immune escape via engagement with IL-17A-producing γδ T cells.Nature communications · 2022Article
- Engineering γδ T Cells: Recognizing and Activating on Their Own Way.Frontiers in immunology · 2022Review
- γδ T cell IFNγ production is directly subverted by Yersinia pseudotuberculosis outer protein YopJ in mice and humans.PLoS pathogens · 2021Article
- γδ T cells in malaria: a double-edged sword.The FEBS journal · 2021Review
- γδT Cells Are Required for CD8Frontiers in immunology · 2021Article
- Microbiota-dependent expansion of testicular IL-17-producing Vγ6Mucosal immunology · 2021Article
- From thymus to periphery: Molecular basis of effector γδ-T cell differentiation.Immunological reviews · 2020Review
- β2 Integrins differentially regulate γδ T cell subset thymic development and peripheral maintenance.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Meningeal γδ T cell-derived IL-17 controls synaptic plasticity and short-term memory.Science immunology · 2019Article
- γδ-T cells promote IFN-γ-dependentProceedings of the National Academy of Sciences of the United States of America · 2019Article
- The Pivotal Role of Regulatory T Cells in the Regulation of Innate Immune Cells.Frontiers in immunology · 2019Review
- Transcription Factor KLF10 Constrains IL-17-Committed Vγ4Frontiers in immunology · 2018Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 4 countries.
Funding
Abstract
γδ T lymphocytes are commonly viewed as embracing properties of both adaptive and innate immunity. Contributing to this is their responsiveness to pathogen products, either with or without the involvement of the TCR and its coreceptors. This study clarifies this paradoxical behavior by showing that these two modes of responsiveness are the properties of two discrete sets of murine lymphoid γδ T cells. Thus, MyD88 deficiency severely impaired the response to malaria infection of CD27((-)), IL-17A-producing γδ T cells, but not of IFN-γ-producing γδ cells. Instead, the latter compartment was severely contracted by ablating CD27, which synergizes with TCRγδ in the induction of antiapoptotic mediators and cell cycle-promoting genes in CD27((+)), IFN-γ-secreting γδ T cells. Hence, innate versus adaptive receptors differentially control the peripheral pool sizes of discrete proinflammatory γδ T cell subsets during immune responses to infection.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.