ArticleJournal of bacteriology2011
Adhesive activity of the haemophilus cryptic genospecies cha autotransporter is modulated by variation in tandem Peptide repeats.
Article in Journal of bacteriology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Article
- The long and the short of Periscope Proteins.Biochemical Society transactions · 2022Review
- Secrete or perish: The role of secretion systems inComputational and structural biotechnology journal · 2021Review
- Burkholderia cenocepacia-host cell contact controls the transcription activity of the trimeric autotransporter adhesin BCAM2418 gene.MicrobiologyOpen · 2020Article
- Polymorphisms of a Collagen-Like Adhesin Contributes toFrontiers in microbiology · 2019Article
- The Haemophilus cryptic genospecies Cha adhesin has at least two variants that differ in host cell binding, bacterial aggregation, and biofilm formation properties.Journal of bacteriology · 2014Article
- The Legionella pneumophila collagen-like protein mediates sedimentation, autoaggregation, and pathogen-phagocyte interactions.Applied and environmental microbiology · 2014Article
- Genetic variation in Saccharomyces cerevisiae: circuit diversification in a signal transduction network.Genetics · 2012Article
- Functional heterogeneity of the UpaH autotransporter protein from uropathogenic Escherichia coli.Journal of bacteriology · 2012Article
- Article
- Article
- Comparative Genome Sequence Analysis Reveals the Extent of Diversity and Conservation for Glycan-Associated Proteins in Burkholderia spp.Comparative and functional genomics · 2012Article
- Variation of intragenic tandem repeat tract of tolA modulates Escherichia coli stress tolerance.PloS one · 2012Article
- Expression during host infection and localization of Yersinia pestis autotransporter proteins.Journal of bacteriology · 2011Article
- The long and the short of bacterial adhesion regulation.Journal of bacteriology · 2011Article
- Trimeric autotransporter adhesins in members of the Burkholderia cepacia complex: a multifunctional family of proteins implicated in virulence.Frontiers in cellular and infection microbiology · 2011Review
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2 authors.
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Abstract
The Haemophilus cryptic genospecies is an important cause of maternal genital tract and neonatal systemic infections and initiates infection by colonizing the genital or respiratory epithelium. In recent work, we identified a unique Haemophilus cryptic genospecies protein called Cha, which mediates efficient adherence to genital and respiratory epithelia. The Cha adhesin belongs to the trimeric autotransporter family and contains an N-terminal signal peptide, an internal passenger domain that harbors adhesive activity, and a C-terminal membrane anchor domain. The passenger domain in Cha contains clusters of YadA-like head domains and neck motifs as well as a series of tandem 28-amino-acid peptide repeats. In the current study, we report that variation in peptide repeat number gradually modulates Cha adhesive activity, associated with a direct effect on the length of Cha fibers on the bacterial cell surface. The N-terminal 404 residues of the Cha passenger domain mediate binding to host cells and also facilitate bacterial aggregation through intermolecular Cha-Cha binding. As the tandem peptide repeats expand, the Cha fiber becomes longer and Cha adherence activity decreases. The expansion and contraction of peptide repeats represent a novel mechanism for modulating adhesive capacity, potentially balancing the need of the organism to colonize the genital and respiratory tracts with the ability to attach to alternative substrates, disperse within the host, or evade the host immune system.
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