ReviewProgress in molecular biology and translational science2010
Driven to be inactive? The genetics of physical activity.
Review in Progress in molecular biology and translational science, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03722797 (Metabolic Cost and Physical Activity in Sedentary Adults With a Unilateral Transtibial Amputation as Compared to Controls), which is not on this map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Metabolic Cost and Physical Activity in Sedentary Adults With a Unilateral Transtibial Amputation as Compared to Controls
Who cites it
12 citing papers in PubMed.
- Adolescent wellbeing is associated with positive outcomes in early adulthood in a sibling comparison study.Nature communications · 2026Article
- Association analysis of the dopaminergic receptor 2 geneBiology of sport · 2025Article
- Review
- Genome-wide association studies of 27 accelerometry-derived physical activity measurements identified novel loci and genetic mechanisms.Genetic epidemiology · 2022Article
- The Role of Dopamine Receptor D2 in Bridging the Intention-Behavior Gap in Sport Participation.International journal of environmental research and public health · 2021Article
- Article
- Effects of varying doses of estrogen and caudal pressure on wheel running in orchidectomized male mice.Physiological reports · 2018Article
- Association of Anthropometric and Lifestyle Parameters with Fitness Levels in Greek Schoolchildren: Results from the EYZHN Program.Frontiers in nutrition · 2018Article
- Role of Inactivity in Chronic Diseases: Evolutionary Insight and Pathophysiological Mechanisms.Physiological reviews · 2017Review
- Sex-specific genetic effects in physical activity: results from a quantitative genetic analysis.BMC medical genetics · 2015Article
- A study of sedentary behaviour in the older Finnish twin cohort: a cross sectional analysis.BioMed research international · 2014Article
- Why control activity? Evolutionary selection pressures affecting the development of physical activity genetic and biological regulation.BioMed research international · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The health implications of physical inactivity, including its integral role in promoting obesity, are well known and have been well documented. Physical activity is a multifactorial behavior with various factors playing a role in determining individual physical activity levels. Research using both human and animal models in the past several years has clearly indicated that genetics is associated with physical activity. Furthermore, researchers have identified several significant and suggestive genomic quantitative trait loci associated with physical activity. To date, the identities of the causal genes underlying physical activity regulation are unclear, with few strong candidate genes. The current research provides a foundation from which future confirmatory research can be launched as well as determination of the mechanisms through which the genetic factors act. The application of this knowledge could significantly augment the information available for physical activity behavior change interventions resulting in more efficient programs for those predisposed to be inactive.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.