ReviewAdvances in enzyme regulation2011
Diphosphoinositol polyphosphates: what are the mechanisms?
Review in Advances in enzyme regulation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed.
- Transcriptomic Signatures of the Foetal Liver and Late Prenatal Development in Vitrified Rabbit Embryos.Veterinary sciences · 2024Article
- Protein kinase- and lipase inhibitors of inositide metabolism deplete IPCellular signalling · 2018Article
- IP6K1 Reduces Mesenchymal Stem/Stromal Cell Fitness and Potentiates High Fat Diet-Induced Skeletal Involution.Stem cells (Dayton, Ohio) · 2017Article
- Suggestive association between variants in IL1RAPL and asthma symptoms in Latin American children.European journal of human genetics : EJHG · 2017Article
- Importance of Radioactive Labelling to Elucidate Inositol Polyphosphate Signalling.Topics in current chemistry (Cham) · 2017Review
- Inositol Pyrophosphates: Energetic, Omnipresent and Versatile Signalling Molecules.Journal of the Indian Institute of Science · 2017Review
- Protein pyrophosphorylation: moving forward.The Biochemical journal · 2016Article
- A Genome-Wide Association Study Identifies Multiple Regions Associated with Head Size in Catfish.G3 (Bethesda, Md.) · 2016Article
- Inositol hexakisphosphate kinase 1 (IP6K1) activity is required for cytoplasmic dynein-driven transport.The Biochemical journal · 2016Article
- Towards pharmacological intervention in inositol pyrophosphate signalling.Biochemical Society transactions · 2016Review
- The emerging roles of inositol pyrophosphates in eukaryotic cell physiology.Journal of biosciences · 2015Review
- Biosynthesis and possible functions of inositol pyrophosphates in plants.Frontiers in plant science · 2015Review
- Inositol pyrophosphates: why so many phosphates?Advances in biological regulation · 2015Review
- Inositol hexakisphosphate kinase-1 mediates assembly/disassembly of the CRL4-signalosome complex to regulate DNA repair and cell death.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Human genome-wide RNAi screen identifies an essential role for inositol pyrophosphates in Type-I interferon response.PLoS pathogens · 2014Article
- Chemical pyrophosphorylation of functionally diverse peptides.Journal of the American Chemical Society · 2014Article
- The enzymes of human diphosphoinositol polyphosphate metabolism.The FEBS journal · 2014Review
- Understanding inositol pyrophosphate metabolism and function: kinetic characterization of the DIPPs.FEBS letters · 2013Article
- PPIP5K1 modulates ligand competition between diphosphoinositol polyphosphates and PtdIns(3,4,5)P3 for polyphosphoinositide-binding domains.The Biochemical journal · 2013Article
- Substrate ambiguity among the nudix hydrolases: biologically significant, evolutionary remnant, or both?Cellular and molecular life sciences : CMLS · 2013Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
In countries where adulthood is considered to be attained at age eighteen, 2011 can be the point at which the diphosphoinositol polyphosphates might formally be described as "coming of age", since these molecules were first fully defined in 1993 (Menniti et al., 1993; Stephens et al., 1993b). But from a biological perspective, these polyphosphates cannot quite be considered to have matured into the status of being independently-acting intracellular signals. This review has discussed several of the published proposals for mechanisms by which the diphosphoinositol polyphosphates might act. We have argued that all of these hypotheses need further development.We also still do not know a single molecular mechanism by which a change in the levels of a particular diphosphoinositol polyphosphate can be controlled. Yet, despite all these gaps in our understanding, there is an enduring anticipation that these molecules have great potential in the signaling field. Reflecting our expectations of all teenagers, it should be our earnest hope that in the near future the diphosphoinositol polyphosphates will finally grow up.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.