Trial reportThe Journal of allergy and clinical immunology2010
Maternal consumption of peanut during pregnancy is associated with peanut sensitization in atopic infants.
Trial report in The Journal of allergy and clinical immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00356174 (A Prospective Cohort Study of Immune Mechanisms, Genetic Factors, and Clinical and Environmental Characteristics Associated With the Occurrence and Clinical Outcome of Food Allergy), which is not on this map. Cited by 53 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective Cohort Study of Immune Mechanisms, Genetic Factors, and Clinical and Environmental Characteristics Associated With the Occurrence and Clinical Outcome of Food Allergy (CoFAR2)
Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it, 178 citations in OpenAlex.
- Risk Factors for the Development of Food Allergy in Infants and Children: A Systematic Review and Meta-Analysis.JAMA pediatrics · 2026Pooled it
- Peanut, milk, and wheat intake during pregnancy is associated with reduced allergy and asthma in children.The Journal of allergy and clinical immunology · 2014Trial
- Maternal IgE Influence on Fetal and Infant Health.Immunological reviews · 2025Review
- Scientific developments in understanding food allergy prevention, diagnosis, and treatment.Frontiers in immunology · 2025Review
- Maternal influences on offspring food allergy.Immunological reviews · 2024Review
- Prenatal Factors in the Development of Allergic Diseases.International journal of molecular sciences · 2024Review
- Review
- The Effect of Breastfeeding on Food Allergies in Newborns and Infants.Children (Basel, Switzerland) · 2023Review
- Oral tolerance as antigen-specific immunotherapy.Immunotherapy advances · 2021Review
- Role of the Microbiome in Allergic Disease Development.Current allergy and asthma reports · 2020Review
- Epidemiology and Burden of Food Allergy.Current allergy and asthma reports · 2020Review
- Nutrition and Avoidance Diets in Children With Food Allergy.Frontiers in pediatrics · 2020Review
- The influence of cultural attitudes to nut exposure on reported nut allergy: A pilot cross sectional study.PloS one · 2020Article
- Appropriate age range for introduction of complementary feeding into an infant's diet.EFSA journal. European Food Safety Authority · 2019Article
- Immunomodulatory effects of breast milk on food allergy.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2019Review
- The Consortium for Food Allergy Research (CoFAR): The first generation.The Journal of allergy and clinical immunology · 2019Article
- Influences of Maternal Factors Over Offspring Allergies and the Application for Food Allergy.Frontiers in immunology · 2019Review
- The association of infant feeding patterns with food allergy symptoms and food allergy in early childhood.International breastfeeding journal · 2019Article
- Prenatal Diet and the Development of Childhood Allergic Diseases: Food for Thought.Current allergy and asthma reports · 2018Review
- Maternal peanut consumption and risk of peanut allergy in childhood.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2018Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundPeanut allergy is typically severe, lifelong, and prevalent.
objectiveTo identify factors associated with peanut sensitization.
methodsWe evaluated 503 infants 3 to 15 months of age (mean, 9.4 months) with likely milk or egg allergy but no previous diagnosis of peanut allergy. A total of 308 had experienced an immediate allergic reaction to cow's milk and/or egg, and 204 had moderate to severe atopic dermatitis and a positive allergy test to milk and/or egg. A peanut IgE level ≥5 kU(A)/L was considered likely indicative of peanut allergy.
resultsA total of 140 (27.8%) infants had peanut IgE levels ≥5 kU(A)/L. Multivariate analysis including clinical, laboratory, and demographic variables showed frequent peanut consumption during pregnancy (odds ratio, 2.9; 95% CI, 1.7-4.9; P < .001), IgE levels to milk (P = .001) and egg (P < .001), male sex (P = .02), and nonwhite race (P = .02) to be the primary factors associated with peanut IgE ≥5 kUA/L. Frequency of peanut consumption during pregnancy and breast-feeding showed a dose-response association with peanut IgE ≥5 kU(A)/L, but only consumption during pregnancy was a significant predictor. Among 71 infants never breast-fed, frequent consumption of peanut during pregnancy was strongly associated with peanut IgE ≥5 kU(A)/L (odds ratio, 4.99, 95% CI, 1.69-14.74; P < .004).
conclusionIn this cohort of infants with likely milk or egg allergy, maternal ingestion of peanut during pregnancy was strongly associated with a high level of peanut sensitization.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.